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. 2023 Dec 4;21:877. doi: 10.1186/s12967-023-04760-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — The efficacy of ND630 and siACACA in PCa in vivo. A Images of tumors derived from PC-3 shNC, PC-3-shcircKIF18B_003 or PC-3-shcircKIF18B_003 + siACACA cells in animals treated with PBS or ND630. B, C Average tumor volume and weight from animals injected with PC-3 shNC, PC-3-shcircKIF18B_003 or PC-3-shcircKIF18B_003 + siACACA cells and treated with PBS or ND630. D IHC assay were used to determine the expression of ACACA, Ki67, and MMP2 in tumors. E Quantification of mean optical density of the protein staining of ACACA, Ki67, and MMP2