Table 3.
Parameters on the organ/tissue level that were estimated to the Fast-food study-data (specifically the initial values of glucose and insulin). For the Topiramate study, the values from [4] where used
| Parameter | Description |
|---|---|
| VG | Distribution volume of glucose |
| k1 | Rate parameter glucose kinetics |
| k2 | Rate parameter glucose kinetics |
| Gb | Basal plasma glucose |
| VI | Distribution volume of insulin |
| m1 | Insulin kinetics rate parameter |
| m2 | Insulin kinetics rate parameter |
| m4 | Insulin kinetics rate parameter |
| m5 | Insulin kinetics rate parameter |
| m6 | Insulin kinetics rate parameter |
| HEb | Baseline hepatic insulin extraction |
| Ib | Basal plasma insulin |
| Sb | Basal insulin secretion |
| kmax | Glucose emptying max rate |
| kmin | Glucose min rate |
| kabs | Rate of intestinal absorption |
| kgri | Rate of grinding |
| f | Fraction of intestinal absorption appears in plasma |
| b | Rate of appearance parameter |
| dd | Rate of appearance parameter |
| kp1 | Extrapolated EGP at zero Glucose and Insulin |
| kp2 | Liver Glucose effectiveness |
| kp3 | Amplitude of insulin action on liver |
| kp4 | Amplitude of portal Insulin action on liver |
| ki | Delay between Insulin signal and Insulin action |
| p2U | Rate constant of Insulin action on the peripheral Glucose utilization |
| K | Pancreatic responsivity to glucose rate of change |
| alpha | Delay between glucose rate of change |
| beta | Pancreatic responsivity to glucose |
| gamma | Transfer rate constant between portal vein & liver |
| ke1 | Rate of renal extraction |
| ke2 | Cut-off for renal extraction |