Table 3.
Meta-analysis of the association between the MCP-1 rs1024611polymorphism and DN risk (DN vs. healthy control)
| Genetic variant | Study group | No. studies | Heterogeneity test | Association test (FE model) | Association test (RE model) | Publication bias | |||
|---|---|---|---|---|---|---|---|---|---|
| I2 | P value | OR (95% CI) | P value | OR (95% CI) | P value | P value* | |||
| GG + GA vs.AA (dominant) | Overall | 7 | 33.5 | 0.172 | 1.27 (1.07–1.51) | 0.007 | 1.25 (0.98–1.60) | 0.072 | 0.770 |
| Population | |||||||||
| Asian | 5 | 30.0 | 0.222 | 1.37 (1.11–1.71) | 0.004 | 1.38 (1.01–1.88) | 0.041 | ||
| Caucasian | 2 | 47.7 | 0.167 | 1.09 (0.82–1.47) | 0.545 | 1.00 (0.60–1.67) | 0.986 | ||
| Genotyping method | |||||||||
| PCR–RFLP | 5 | 0.0 | 0.539 | 1.12 (0.88–1.42) | 0.354 | 1.12 (0.88–1.42) | 0.355 | ||
| ARMS-PCR | 2 | 72.8 | 0.055 | 1.48 (1.14–1.91) | 0.003 | 1.87 (0.83–4.19) | 0.128 | ||
| GG vs. GA + AA (recessive) | Overall | 7 | 60.6 | 0.019 | 1.17 (0.93–1.47) | 0.178 | 1.19 (0.79–1.78) | 0.400 | 0.934 |
| Population | |||||||||
| Asian | 5 | 66.1 | 0.019 | 1.24 (0.96–1.59) | 0.100 | 1.26 (0.80–2.00) | 0.324 | ||
| Caucasian | 2 | 71.5 | 0.061 | 0.92 (0.54–1.56) | 0.752 | 0.45 (0.79–1.78) | 0.556 | ||
| Genotyping method | |||||||||
| PCR–RFLP | 5 | 25.1 | 0.254 | 0.88 (0.66–1.18) | 0.407 | 0.92 (0.65–1.32) | 0.669 | ||
| ARMS-PCR | 2 | 19.4 | 0.265 | 1.92 (1.31–2.81) | 0.001 | 1.96 (1.25–3.07) | 0.003 | ||
| GG vs.AA (homozygote model) | Overall | 7 | 57.8 | 0.027 | 1.42 (1.09–1.86) | 0.010 | 1.40 (0.88–2.23) | 0.160 | 0.984 |
| Population | |||||||||
| Asian | 5 | 58.8 | 0.046 | 1.61 (1.18–2.19) | 0.003 | 1.55 (0.92–2.63) | 0.099 | ||
| Caucasian | 2 | 73.9 | 0.050 | 0.97 (0.56–1.68) | 0.907 | 0.45 (0.03–7.30) | 0.576 | ||
| Genotyping method | |||||||||
| PCR–RFLP | 5 | 19.3 | 0.291 | 1.02 (0.72–1.45) | 0.918 | 1.07 (0.70–1.63) | 0.763 | ||
| ARMS-PCR | 2 | 64.3 | 0.094 | 2.28 (1.50–3.47) | < 0.001 | 2.70 (1.13–6.43) | 0.025 | ||
| GG vs.GA (heterozygote model) | Overall | 7 | 44.8 | 0.093 | 1.06 (0.83–1.50) | 0.652 | 1.08 (0.76–1.54) | 0.676 | 0.821 |
| Population | |||||||||
| Asian | 5 | 49.5 | 0.094 | 1.11 (0.85–1.45) | 0.445 | 1.13 (0.75–1.68) | 0.564 | ||
| Caucasian | 2 | 66.4 | 0.085 | 0.86 (0.49–1.50) | 0.594 | 0.46 (0.04–5.16) | 0.532 | ||
| Genotyping method | |||||||||
| PCR–RFLP | 5 | 14.1 | 0.324 | 0.83 (0.61–1.13) | 0.229 | 0.87 (0.61–1.22) | 0.414 | ||
| ARMS-PCR | 2 | 0.0 | 0.563 | 1.62 (1.08–2.43) | 0.019 | 1.62 (1.08–2.43) | 0.019 | ||
| G vs. A (allele contrast model) | Overall | 7 | 67.2 | 0.006 | 1.17 (1.04–1.33) | 0.010 | 1.13 (0.89–1.43) | 0.304 | 0.892 |
| Population | |||||||||
| Asian | 5 | 68.3 | 0.013 | 1.23 (1.07–1.42) | 0.004 | 1.23 (0.92–1.64) | 0.166 | ||
| Caucasian | 2 | 76.5 | 0.039 | 1.04 (0.83–1.33) | 0.754 | 0.87 (0.46–1.67) | 0.684 | ||
| Genotyping method | |||||||||
| PCR–RFLP | 5 | 32.8 | 0.203 | 1.01 (0.86–1.19) | 0.877 | 0.98 (0.80–1.21) | 0.886 | ||
| ARMS-PCR | 2 | 80.2 | 0.025 | 1.43 (1.19–1.72) | < 0.001 | 1.70 (0.94–3.05) | 0.078 | ||
Abbreviations: No. Number, RE Random-effects, FE Fixed-effects, PCR–RFLP Polymerase chain reaction-restriction fragment length polymorphism, ARMS-PCR Amplification refractory mutation detection system-polymerase chain reaction
* Publication bias test (Egger’s test)