Table 2.

Intervention, sedation monitoring, and study outcomes

	Remimazolam (n = 30)	Propofol (n = 30)	P value
Intervention and sedation monitoring
Study drug treatment
Duration of infusion, h	48.0 (21.5, 48.0)	28.0 (23.5, 48.0)	0.234
Infusion rate, mg/kg/h	0.60 (0.45, 1.07)	2.53 (1.94, 2.94)	–
Infusion rate of remifentanil, μg/kg/h	6.0 (6.0, 6.3)	6.0 (5.7, 6.1)	0.099
Received rescue sedation	3 (10.0%)	0 (0.0%)	0.237
Received neuromuscular blockers	12 (40.0%)	7 (23.3%)	0.165
Received norepinephrine	21 (70.0%)	24 (80.0%)	0.371
Infusion rate, μg/kg/min	0.06 (0.01, 0.19)	0.07 (0.04, 0.31)	0.148
Prone positioning	12 (40.0%)	7 (23.3%)	0.165
RASS score	− 5.0 (− 5.0, − 4.0)	− 5.0 (− 5.0, − 4.0)	0.717
Narcotrend Index value	28.0 (21.0, 37.0)	29.0 (21.0, 37.0)	0.920
Primary outcome
Percentage of time with a RASS score of -4 or -5 without rescue sedation, %	100 (96.9, 100)	100 (100, 100)	0.168
Secondary outcomes
Ventilator-free hours within 7 days, h	0.0 (0.0, 34.1)	0.0 (0.0, 3.3)	0.256
Successful extubation	13 (43.3%)	7 (23.3%)	0.100
Length of ICU stay, days	23.5 (8.0, 28.0)	28.0 (8.75, 28.0)	0.841
28-day mortality	11 (39.3%)	17 (60.7%)	0.121
Adverse events
Hypotension	16 (53.3%)	18 (60.0%)	0.602
Hypotension with intervention	5 (16.7%)	7 (23.3%)	0.519
Bradycardia	0 (0.0%)	0 (0.0%)	–

Data are number (%), mean (SD), or median (interquartile range)

ICU: Intensive Care Medicine; RASS: Richmond Agitation and Sedation Scale