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. 2005 Mar 23;33(6):1790–1803. doi: 10.1093/nar/gki319

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Uranyl cleavage of human cytomegalovirus: effect of spermidine. (A) Densitometric scans of an autoradiograph showing uranyl cleavage of the human CMV promoter in the absence and presence of 1 mM spermidine. The DNA sequence is annotated on the scans and covers from −80 to −120 bp and (B) same content as in (A), but the densitometric scan covers from −10 to −70 bp upstream from the transcription start site. Binding sites for transcription factor Sp1 and NF-κB are indicated above the sequence in (A and B). (C) Differential cleavage plot comparing the susceptibility of the human CMV promoter to uranyl cleavage in the absence and presence of 1 mM spermidine. The analysis covers from −80 to −120 bp upstream from the transcription start site. Black boxes indicate the position of A-tracts. (D) Same as in (C) but the differential cleavage plot analysis covers from −10 to −60 bp upstream from the transcription start site of the human CMV promoter. Black boxes indicate the position of A-tracts.

Uranyl cleavage of human cytomegalovirus: effect of spermidine. (A) Densitometric scans of an autoradiograph showing uranyl cleavage of the human CMV promoter in the absence and presence of 1 mM spermidine. The DNA sequence is annotated on the scans and covers from −80 to −120 bp and (B) same content as in (A), but the densitometric scan covers from −10 to −70 bp upstream from the transcription start site. Binding sites for transcription factor Sp1 and NF-κB are indicated above the sequence in (A and B). (C) Differential cleavage plot comparing the susceptibility of the human CMV promoter to uranyl cleavage in the absence and presence of 1 mM spermidine. The analysis covers from −80 to −120 bp upstream from the transcription start site. Black boxes indicate the position of A-tracts. (D) Same as in (C) but the differential cleavage plot analysis covers from −10 to −60 bp upstream from the transcription start site of the human CMV promoter. Black boxes indicate the position of A-tracts.