Table I.
HERV-K proviruses expressed at elevated levels in SLE.
| Chromosomal location | Strand | Transcript designation | Synonyms | Comments |
|---|---|---|---|---|
| 1q22a (155,599,135–155,604,668) | − | HERVK-int_dup15 | K102, ERVK7 | full-length type 1 provirus |
| 3q12.3 (101,411,706–101,417,184) | + | HERVK-int_dup37 | ERVK5 | Gag, but not Pol or Env |
| 4q31.3 (154,610,027–154,615,070) | − | HERVK9-int_dup190 | NA | incomplete, short ORFs |
| 7p22.1a (4,623,025–4,630,560) | − | HERVK-int_dup102 | K108L, ERVK6 | full-length type 2 provirus |
| 7p22.1b (4,631,529–4,639,063) | − | HERVK-int_dup103 | K108R, ERVK6 | full-length type 2 provirus |
| 12p13.31 (8,711,047–8,715,066) | − | HERVK22-int_dup314 | NA | 3’ truncated, stop codons |
| 12q12 (42,837,368–42,840,271) | + | HERVK22-int_dup317 | periphilin1 | 3’ truncated, stop codons |
| 16p13.3a (2,711,289–2,718,374) | − | HERVK13-int_dup43 | NA | 3’,5’truncated, stop codons |
| 16p13.3b (3,127,354–3,131,057) | − | HERVK9-int_dup555-558 | NA | insertions, stop codons |
| 19q13.43c (58,824,957–58,825,710) | + | HERVK3-int_dup298 | NA | insertions, stop codons |