Alignment of H2 ORF orthologs from representative poxviruses. The alignment includes one representative sequence from each genus of Chordopoxvirinae and the two complete Entomopoxvirinae sequences. Virus abbreviation, name, and genus are as follows: VAC, vaccinia virus, Orthopoxvirus; MYX, myxoma virus, Leporipoxvirus; LSDV, lumpy skin disease virus, Capripoxvirus; SPV, swinepox virus, Suipoxvirus; YMTV, Yaba monkey tumor virus, Yatapoxvirus; BPSV, bovine papular stomatitis virus, Parapoxvirus; MCV, molluscum contagiosum virus, Molluscipoxvirus; FPV, fowlpox virus, Avipoxvirus; AMV, Amsacta moorei entomopoxvirus, Entomopoxvirus B; MSV, Melanoplus sanguinipes entomopoxvirus, Entomopoxvirus B. Invariant amino acid residues are shaded grey, and conserved cysteines are indicated additionally by asterisks. TM, predicted transmembrane domain. The predicted secondary structure (SS), consisting of several putative β-strands (E) alternating with α-helices (H), is shown.