Table 2:
Event-Related Design ROI Reward Anticipation (Reward Anticipation>Loss Anticipation) and Outcome (Reward Outcome>Loss Outcome) Activation, Life Stress, and their Interaction1 Predicting Depressive Symptoms
| Measure | b | β | SE | Est./SE | p | q | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Left Amygdala | Stress Frequency** | 1.164 | 0.341 | 0.280 | 4.156 | <.001 | |
| Outcome Activation | 0.004 | 0.013 | 0.021 | 0.167 | .868 | ||
| Anticipation Activation | 0.024 | 0.086 | 0.022 | 1.086 | .279 | ||
| Sex* | 0.973 | 0.165 | 0.468 | 2.080 | .039 | ||
| Age* | −0.852 | −0.277 | 0.241 | −3.534 | .001 | ||
| Stress Frequency x Outcome Activation | 0.012 | 0.075 | 0.013 | 0.959 | .340 | .603 | |
| Stress Frequency x Anticipation Activation * | −0.043 | −0.265 | 0.013 | −3.368 | .001 | .006 | |
| Right Amygdala | Stress Frequency** | 1.127 | 0.330 | 0.285 | 3.953 | <.001 | |
| Outcome Activation | −0.014 | −0.050 | 0.023 | −0.639 | .524 | ||
| Anticipation Activation | 0.028 | 0.098 | 0.023 | 1.202 | .232 | ||
| Sex | 0.859 | 0.145 | 0.481 | 1.787 | .076 | ||
| Age* | −0.849 | −0.276 | 0.245 | −3.459 | .001 | ||
| Stress Frequency x Outcome Activation | 0.004 | 0.024 | 0.013 | 0.307 | .759 | .759 | |
| Stress Frequency x Anticipation Activation * | −0.038 | −0.230 | 0.013 | −2.847 | .005 | .015 | |
| Left NAc | Stress Frequency** | 1.144 | 0.335 | 0.282 | 4.052 | <.001 | |
| Outcome Activation | 0.018 | 0.070 | 0.020 | 0.904 | .368 | ||
| Anticipation Activation | 0.001 | 0.006 | 0.020 | 0.074 | .941 | ||
| Sex | 0.931 | 0.157 | 0.473 | 1.968 | .051 | ||
| Age* | −0.810 | −0.263 | 0.242 | −3.342 | .001 | ||
| Stress Frequency x Outcome Activation | −0.009 | −0.065 | 0.010 | −0.842 | .402 | .603 | |
| Stress Frequency x Anticipation Activation * | −0.030 | −0.195 | 0.012 | −2.503 | .014 | .027 | |
| R NAc | Stress Frequency** | 1.152 | 0.337 | 0.279 | 4.128 | <.001 | |
| Outcome Activation | 0.016 | 0.059 | 0.022 | 0.763 | .447 | ||
| Anticipation Activation | −0.004 | −0.016 | 0.021 | −0.194 | .847 | ||
| Sex* | 0.992 | 0.168 | 0.485 | 2.044 | .043 | ||
| Age* | −0.813 | −0.264 | 0.243 | −3.347 | .001 | ||
| Stress Frequency x Outcome Activation | −0.006 | −0.035 | 0.013 | −0.463 | .644 | .759 | |
| Stress Frequency x Anticipation Activation * | −0.031 | −0.190 | 0.013 | −2.387 | .018 | .027 | |
| Left mPFC | Stress Frequency** | 1.150 | 0.337 | 0.280 | 4.103 | <.001 | |
| Outcome Activation | 0.027 | 0.117 | 0.018 | 1.475 | .142 | ||
| Anticipation Activation | 0.008 | 0.036 | 0.017 | 0.456 | .649 | ||
| Sex | 0.790 | 0.134 | 0.489 | 1.618 | .108 | ||
| Age* | −0.821 | −0.267 | 0.244 | −3.372 | .001 | ||
| Stress Frequency x Outcome Activation | 0.011 | 0.091 | 0.010 | 1.133 | .259 | .603 | |
| Stress Frequency x Anticipation Activation | −0.020 | −0.151 | 0.011 | −1.812 | .072 | .072 | |
| Right mPFC | Stress Frequency** | 1.156 | 0.339 | 0.280 | 4.126 | <.001 | |
| Outcome Activation | 0.024 | 0.106 | 0.018 | 1.323 | .188 | ||
| Anticipation Activation | 0.007 | 0.035 | 0.017 | 0.433 | .666 | ||
| Sex | 0.879 | 0.149 | 0.480 | 1.829 | .070 | ||
| Age* | −0.821 | −0.267 | 0.244 | −3.359 | .001 | ||
| Stress Frequency x Outcome Activation | 0.010 | 0.079 | 0.010 | 0.942 | .348 | .603 | |
| Stress Frequency x Anticipation Activation* | −0.022 | −0.172 | 0.011 | −1.993 | .048 | .058 | |
Note.
*
p<.05
**
p<.001. Bold=q<.05 across ROIs within the family of anticipation or outcome analyses. Sex coded 1=female, −1=male.