Table 3:
Event-Related Design ROI Reward Anticipation (Reward Anticipation>Loss Anticipation) and Outcome (Reward Outcome>Neutral Outcome) Activation, Life Stress, and their Interaction Predicting1 Depressive Symptoms
| Measure | b | β | SE | Est./SE | p | q | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Left Amygdala | Stress Frequency** | 1.138 | 0.333 | 0.273 | 4.174 | <.001 | |
| Outcome Activation | <0.001 | <0.001 | 0.023 | −0.001 | .999 | ||
| Anticipation Activation | 0.021 | 0.073 | 0.023 | 0.921 | .358 | ||
| Sex* | 0.938 | 0.159 | 0.467 | 2.008 | .047 | ||
| Age* | −0.813 | −0.264 | 0.240 | −3.392 | .001 | ||
| Stress Frequency x Outcome Activation | −0.012 | −0.063 | 0.014 | −0.808 | .420 | .504 | |
| Stress Frequency x Anticipation Activation * | −0.042 | −0.260 | 0.013 | −3.288 | .001 | .006 | |
| Right Amygdala | Stress Frequency** | 1.129 | 0.331 | 0.275 | 4.114 | <.001 | |
| Outcome Activation | −0.024 | −0.076 | 0.025 | −0.953 | .342 | ||
| Anticipation Activation | 0.024 | 0.086 | 0.023 | 1.058 | .292 | ||
| Sex | 0.831 | 0.141 | 0.477 | 1.741 | .084 | ||
| Age* | −0.826 | −0.268 | 0.241 | −3.426 | .001 | ||
| Stress Frequency x Outcome Activation | −0.013 | −0.077 | 0.013 | −0.977 | .331 | .497 | |
| Stress Frequency x Anticipation Activation * | −0.041 | −0.249 | 0.013 | −3.109 | .002 | .006 | |
| Left NAc | Stress Frequency** | 1.108 | 0.324 | 0.276 | 4.011 | <.001 | |
| Outcome Activation | 0.024 | 0.087 | 0.022 | 1.091 | .277 | ||
| Anticipation Activation | −0.003 | −0.011 | 0.020 | −0.144 | .886 | ||
| Sex | 0.906 | 0.153 | 0.470 | 1.926 | .056 | ||
| Age* | −0.804 | −0.261 | 0.240 | −3.348 | .001 | ||
| Stress Frequency x Outcome Activation | −0.017 | −0.132 | 0.011 | −1.630 | .106 | .497 | |
| Stress Frequency x Anticipation Activation * | −0.033 | −0.212 | 0.013 | −2.593 | .011 | .017 | |
| Right NAc | Stress Frequency** | 1.115 | 0.327 | 0.277 | 4.022 | <.001 | |
| Outcome Activation | 0.011 | 0.036 | 0.023 | 0.468 | .640 | ||
| Anticipation Activation | −0.005 | −0.020 | 0.021 | −0.252 | .801 | ||
| Sex | 0.959 | 0.162 | 0.484 | 1.982 | .050 | ||
| Age* | −0.811 | −0.264 | 0.242 | −3.347 | .001 | ||
| Stress Frequency x Outcome Activation | −0.015 | −0.090 | 0.013 | −1.152 | .251 | .497 | |
| Stress Frequency x Anticipation Activation * | −0.034 | −0.211 | 0.013 | −2.583 | .011 | .017 | |
| Left mPFC | Stress Frequency** | 1.116 | 0.327 | 0.282 | 3.963 | <.001 | |
| Outcome Activation | 0.009 | 0.035 | 0.020 | 0.447 | .656 | ||
| Anticipation Activation | 0.009 | 0.040 | 0.017 | 0.501 | .617 | ||
| Sex | 0.926 | 0.157 | 0.487 | 1.901 | .060 | ||
| Age* | −0.796 | −0.259 | 0.247 | −3.227 | .002 | ||
| Stress Frequency x Outcome Activation | −0.005 | −0.031 | 0.012 | −0.393 | .695 | .695 | |
| Stress Frequency x Anticipation Activation | −0.016 | −0.120 | 0.011 | −1.484 | .140 | .140 | |
| Right mPFC | Stress Frequency** | 1.086 | 0.318 | 0.279 | 3.889 | <.001 | |
| Outcome Activation | 0.008 | 0.029 | 0.021 | 0.370 | .712 | ||
| Anticipation Activation | 0.006 | 0.030 | 0.017 | 0.366 | .715 | ||
| Sex* | 0.981 | 0.166 | 0.480 | 2.042 | .043 | ||
| Age* | −0.789 | −0.256 | 0.244 | −3.227 | .002 | ||
| Stress Frequency x Outcome Activation | −0.015 | −0.101 | 0.011 | −1.295 | .197 | .497 | |
| Stress Frequency x Anticipation Activation | −0.017 | −0.135 | 0.010 | −1.689 | .094 | .113 | |
Note.
*
p<.05
**
p<.001. Bold=q<.05 across ROIs within the family of anticipation or outcome analyses. Sex coded 1=female, −1=male.