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. 2023 Dec 4;17:e20230012. doi: 10.1590/1980-5764-DN-2023-0012

Figure 1. Oxidative stress interplay with brain-derived neurotrophic factors in Alzheimer’s disease neuropathology.

Figure 1

Abbreviations: Aβ, amyloid-β; aMCI, amnestic mild cognitive impairment; APP, amyloid precursor protein; APOE, apolipoprotein E; BER, base excision repair; BDNF, brain-derived neurotrophic factor; cAMP, cyclic adenosine monophosphatase; CBP, CREB-binding protein; CREB, cAMP response element-binding protein; ETC, electron transport chain; GSK3, glycogen synthase kinase 3; JNK, c-jun N-terminal kinase; LTP/D, long term potentiation/depression; mtDNA, mitochondrial DNA; NFTs, non-fibrillary tangles; P13K/AKT, phosphatidylinositol 3-kinase/protein kinase B; p38MAPK, p38 mitogen-activated protein kinase; p75NTR, p75 neurotrophin receptor; PDE4, phosphodiesterase 4; PKA, protein kinase A; PKC, protein kinase C; ROS, reactive oxygen species; Tr-kB, tropomyosin receptor kinase B.