Figure 2. Brain-derived neurotrophic factor synthesis, functions and sources.
Abbreviations: BBB, blood-brain barrier; BDNF, brain-derived neurotrophic factor; ER, endoplasmic reticulum; GABAergic, gamma-aminobutyric acidergic); LTP/D, long term potentiation/depression; mBDNF, mature-BDNF; PC 1-7, proprotein convertase 1 to 7; p75NTR/Sortilin Complex, p75 neurotrophin receptor complexed with sortilin; PD, pro-domain; SG, secretory granules; SP, signal peptide; TGN, trans-Golgi network; tPA, tissue plasminogen activator; TrkB, tropomyosin-related receptor kinase B; GluN2B/NMDAR, GluN2B containing N-methyl-D-aspartate/NMDA receptors; VCR, vesicles for consecutive release.