FIG. 4.

Prion-associated pathology at 19 weeks postinoculation. PrP staining was performed by 6H4 immunolabeling of brains of NBH-treated (a) and ME7-infected (b) mice, with clear diffuse staining throughout the hippocampus and thalamus and more punctate staining in the dorsal thalamus and dentate gyrus/CA3. Hematoxylin-stained sections through the hippocampi of NBH-treated (c) and ME7-injected (d) animals show marked neurodegeneration of the pyramidal neurons of the hippocampal CA1. Bar = 1 mm (a) or 50 μm (d).