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. 2023 Dec 1;102(48):e36242. doi: 10.1097/MD.0000000000036242

Table 3.

Prognostic factors for overall and disease-free survival (n = 264).

OS DFS
Univariate P Multivariate P Univariate P Multivariate P
HR (95% CI) HR (95% CI) HR (95% CI) HR (95% CI)
Age (y) .390 .941
≥60
<60 0.743 (0.378–1.462) 1.025 (0.541–1.940)
Gender .437 .459
Male
Female 1.311 (0.662–2.597) 1.276 (0.670–2.429)
T classification .096 .120
T4a
T4b 2.030 (0.882–4.672) 1.918 (0.843–4.363)
N classification <.001 .019 <.001 .001
N0
N1
N2 5.747 (2.681–12.200) 3.435 (1.414–8.264) 6.410 (3.086–13.333) 4.405 (1.984–9.804)
Tumor size (cm) .533 .687
≥6
<6 0.807 (0.412–1.583) 0.877 (0.463–1.662)
Cancer nodules .964 .770
Positive
Negative 0.976 (0.344–2.773) 1.167 (0.414–3.290)
Perineural invasion .286 .154
Positive
Negative 0.619 (0.256–1.495) 0.550 (0.242–1.250)
Vascular invasion .021 .890 .005 .283
Positive
Negative 0.355 (0.147–0.857) 0.929 (0.326–2.642) 0.311 (0.137–0.706) 0.610 (0.247–1.506)
Differentiation <.001 .011 .003 .053
Well
Moderate
Poor 3.603 (1.815–7.151) 2.583 (1.243–5.367) 2.776 (1.413–5.456) 1.936 (0.991–3.785)
ASA .413 .578
1
2
3 0.557 (0.228–1.363) 0.910 (0.277–2.985)
CA199 (ug/L) .003 .108 .013 .263
≥37
<37 0.352 (0.176–0.704) 0.534 (0.249–1.146) 0.428 (0.219–0.837) 0.662 (0.321–1.364)
CA125 (ug/L) .129 .078
≥35
<35 0.505 (0.209–1.219) 0.478 (0.211–1.087)
CEA (ug/L) .562 .881
≥5
<5 0.827 (0.435–1.573) 0.956 (0.531–1.722)
AFP (ug/L) .038 .434 .066
≥25
<25 0.120 (0.016–0.886) 0.408 (0.043–3.870) 0.155 (0.021–1.134)
Procedure .952 .503
RHC
TCR
LHC 1.114 (0.452–2.747) 0.690 (0.251–1.898)

ASA = American Society of Anesthesiologists, CI = confidence interval, DFS = disease-free survival, HR = hazard ratios, LHC = left hemicolectomy, OS = overall survival, RHC = right hemicolectomy, TCR = transverse colon resection.