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. 2023 Dec 1;102(48):e36366. doi: 10.1097/MD.0000000000036366

Table 1.

Risk factors of cerebral venous thrombosis.[5,12,1436]

Prothrombotic states Infection (12%)[5,14,2628]
Hereditary conditions (34–41%)[5,12,1418] 1. ENT and face infection (8.2–11%)
2. Systemic infectious diseases (4.3%)
3. Meningitis (2.1%)
1. Prothrombin G20210A mutation (9–21%)
2. Factor V Leiden mutation (9–13%)
3. MTHFR mutation (4.5%)
4. Antithrombin deficiency (3%)
5. Protein C deficiency (2–5%)
6. Protein S deficiency (2–3%)
Mechanical causes[5,12,2730]
1. Lumbar puncture (1.9%)
2. Head trauma (1.1%)
3. Jugular vein catheterization (1%)
4. Neurosurgical procedures (0.6%)
5. Trauma to cerebral sinuses
Acquired conditions (15.7%)[5,12,14,1719]
1. Pregnancy and puerperium (11–59%)
2. Antiphospholipid antibody syndrome (6–17%)
3. Nephrotic syndrome (0.6–1%)
4. Hyperhomocysteinemia
Malignancy (7.4%)[3032]
1. CNS tumors
2. Systemic malignancies
3. Myeloproliferative neoplasms
Haematology[5,12,14,20] Drugs[5,12,14,30,33,34]
1. Severe anemia (9–27%)
2. Polycythaemia
3. Thrombotic thrombocytopenic purpura
4. Heparin-induced thrombocytopenia
1. Oral contraceptives (54–71%)
2. Hormone replacement therapy (4.3%)
3. Cytotoxic drugs (0.8%)
4. Intravenous immunoglobulin
5. Steroids
Autoimmune and Inflammatory diseases[5,14,2125] Miscellaneous[12,14,30,35,36]
1. Inflammatory bowel disease (1.6–3%)
2. Systemic lupus erythematosus (1%)
3. Behçet’s disease (1%)
4. Sarcoidosis (<1%)
5. Thyrotoxicosis (1.7%)
6. COVID-19 vaccine (<1%)
1. Obesity (23%)
2. Dehydration (1.9%)
3. Dural A-V fistulae (1.6%)
4. Arteriovenous malformations (0.2%)
5. No identifiable reasons (12.5%)

Methylenetetrahydrofolate Reductase (MTHFR); ENT- Ear, Nose, and Throat.

Percentage (%) denotes the prevalence of the risk factors. The data expressed in the table were obtained from original research works and review literature.[5,12,1436]