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Amino acid sequences of the E57 and EJB escape viruses. Escape viruses were generated, amplified, and characterized as described in Materials and Methods. (A) E57 escape virus glycoprotein sequences. (B) EJB escape virus glycoprotein sequences. The relevant amino acids harboring the mutations of each escape virus are depicted. Boxed amino acids indicate the identified minimal binding region required for CR57 recognition.
