Table 2.
Genotypes and allele distributions in patients with CAD and control subjects (Han population).
| Total | Men | Women | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAD | Control | P value | CAD | Control | P value | CAD | Control | P value | ||||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |||||||
| rs1801693 | Genotype | T/T | 103 (26.3) | 120 (27.3) | .473 | 76 (28.0) | 49 (22.7) | .025* | 27 (22.3) | 71 (31.8) | .136 | |
| (SNP1) | C/C | 72 (18.4) | 93 (21.2) | 48 (17.7) | 60 (27.8) | 24 (19.8) | 33 (14.8) | |||||
| C/T | 217 (55.4) | 226 (51.5) | 147 (54.2) | 107 (49.5) | 70 (57.9) | 119 (53.4) | ||||||
| Dominant model | TT | 103 (26.3) | 120 (27.3) | .731 | 76 (28.0) | 49 (22.7) | .179 | 27 (22.3) | 71 (31.8) | .062 | ||
| CT + CC | 289 (73.7) | 319 (72.7) | 195 (72.0) | 167 (77.3) | 94 (77.7) | 152 (68.2) | ||||||
| Recessive model | CC | 72 (18.4) | 93 (21.2) | .310 | 48 (17.7) | 60 (27.8) | .008* | 24 (19.8) | 33 (14.8) | .230 | ||
| CT + TT | 320 (81.6) | 346 (78.8) | 223 (82.3) | 156 (72.2) | 97 (80.2) | 190 (85.2) | ||||||
| Allele | T | 423 (54.0) | 466 (53.1) | .720 | 299 (55.2) | 205 (47.5) | .016* | 124 (51.2) | 261 (58.5) | .662 | ||
| C | 361 (46.0) | 412 (46.9) | 243 (44.8) | 227 (52.5) | 118 (48.8) | 185 (41.5) | ||||||
| rs6923877 | Genotype | G/G | 57 (14.5) | 89 (20.3) | .021* | 40 (14.8) | 48 (22.2) | .069 | 17 (14.0) | 41 (18.4) | .300 | |
| (SNP2) | A/A | 118 (30.1) | 146 (33.3) | 79 (29.2) | 65 (30.1) | 39 (32.2) | 81 (36.3) | |||||
| A/G | 217 (55.4) | 204 (46.5) | 152 (56.0) | 103 (47.7) | 65 (53.7) | 101 (45.3) | ||||||
| Dominant model | GG | 57 (14.5) | 89 (20.3) | .030* | 40 (14.8) | 48 (22.2) | .033* | 17 (14.0) | 41 (18.4) | .305 | ||
| AG + AA | 335 (85.5) | 350 (79.7) | 231 (85.2) | 168 (77.8) | 104 (86.0) | 182 (81.6) | ||||||
| Recessive model | AA | 118 (30.1) | 146 (33.3) | .329 | 79 (29.2) | 65 (30.1) | .821 | 39 (32.2) | 81 (36.3) | .447 | ||
| AG + GG | 274 (69.9) | 293 (66.7) | 192 (70.8) | 151 (69.9) | 82 (67.8) | 142 (63.7) | ||||||
| Allele | G | 331 (42.2) | 382 (43.5) | .596 | 232 (42.8) | 199 (46.1) | .308 | 99 (40.9) | 183 (41.0) | .975 | ||
| A | 453 (57.8) | 496 (56.5) | 310 (57.2) | 233 (53.9) | 143 (59.1) | 263 (59.0) | ||||||
| rs9364559 | Genotype | A/A | 182 (46.4) | 221 (50.3) | .419 | 130 (48.0) | 97 (44.9) | .790 | 52 (43.0) | 124 (55.6) | .055 | |
| (SNP3) | G/G | 41 (10.5) | 37 (8.4) | 110 (40.6) | 92 (42.6) | 10 (8.3) | 10 (4.5) | |||||
| A/G | 169 (43.1) | 181 (41.2) | 31 (11.4) | 27 (12.5) | 59 (48.8) | 89 (39.9) | ||||||
| Dominant model | AA | 182 (46.4) | 221 (50.3) | .260 | 130 (48.0) | 97 (44.9) | .501 | 52 (43.0) | 124 (55.6) | .025* | ||
| AG + GG | 210 (53.6) | 218 (49.7) | 141 (52.0) | 119 (55.1) | 69 (57.0) | 99 (44.4) | ||||||
| Recessive model | GG | 41 (10.5) | 37 (8.4) | .316 | 31 (11.4) | 27 (12.5) | .720 | 10 (8.3) | 10 (4.5) | .153 | ||
| AG + AA | 351 (89.5) | 402 (91.6) | 240 (88.6) | 189 (87.5) | 111 (91.7) | 213 (95.5) | ||||||
| Allele | A | 533 (68.0) | 623 (71.0) | .189 | 370 (68.3) | 286 (66.2) | .495 | 163 (67.4) | 337 (75.6) | .021* | ||
| G | 251 (32.0) | 255 (29.0) | 172 (31.7) | 146 (33.8) | 79 (32.6) | 109 (24.4) | ||||||
The P value of genotype was calculated by Fisher exact test.
CAD = coronary artery disease.
*
P < .05.