TABLE 1.
Characteristics of the Study Population During ICU Days 1–7 Based on Delirium Occurrence After Multiple Imputation by Chained Equations Use
| Total (n = 4,064) | Delirium Ever (n = 1,250) | Delirium Never (n = 2,814) | |
|---|---|---|---|
| Baseline characteristics | |||
| Age, median (IQR), yr | 64 (53–72) | 65 (55–74) | 63 (51–71) |
| Sex, male, n (%) | 2,582 (63.5) | 832 (66.6) | 1,750 (62.2) |
| Charlson Comorbidity Scale Score, median (IQR) | 1 (0–2) | 1 (0–2) | 1 (0–2) |
| Body mass index, median (IQR) | 25.7 (22.9–29.1) | 25.5 (22.9–28.7) | 25.7 (22.8–29.3) |
| Admission type, n (%) | |||
| Medical | 1,531 (37.7) | 581 (46.5) | 950 (33.8) |
| Elective surgery | 1,744 (42.9) | 360 (28.8) | 1,384 (49.2) |
| Acute surgery | 789 (19.4) | 309 (24.7) | 480 (17.1) |
| Acute Physiology and Chronic Health Evaluation IV score, median (IQR) | 55 (40–76) | 68 (52–85) | 50 (36–69) |
| Daily ICU characteristics | |||
| Days of no pain, median (IQR) | 1 (1–3) | 2 (1–3) | 1 (1–2) |
| Presence of any pain, n (%) | 2,444 (60.1) | 744 (59.5) | 1,699 (60.4) |
| Days of mild pain, median (IQR) | 1.0 (1.0–2.0) | 2.0 (1.0–3.0) | 1.0 (1.0–2.0) |
| Days of moderate pain, median (IQR) | 1.0 (1.0–2.0) | 1.0 (1.0–2.0) | 1.0 (1.0–2.0) |
| Days of severe pain, median (IQR) | 1.0 (1.0–1.0) | 1 (1–1.6) | 1.0 (1.0–1.0) |
| Maximum modified Sequential Organ Failure Assessment score, median (IQR) | 6 (4-9) | 8 (7–11) | 6 (4–8) |
| Use of invasive mechanical ventilation, n (%) | 3,734 (91.2) | 1,199 (95.9) | 2,535 (90.1) |
| Days of invasive mechanical ventilation, median (IQR) | 2 (1–5) | 5 (2–7) | 2 (1–3) |
| Benzodiazepine use, n (%) | 1982 (48.8) | 833 (66.6) | 1149 (40.8) |
| Days of benzodiazepine use, median (IQR) | 2(1–3) | 2 (1–4) | 1 (1–2) |
| Opioid use, n (%) | 3,384 (83.3) | 1,092 (87.4) | 2,292 (81.4) |
| Days of opioid use, median (IQR) | 2 (1–4) | 4 (2–6) | 1 (1–3) |
IQR = interquartile range.