TABLE 2.
Comparison of Individual ICU Days 1–7 Characteristics Between Each Mental State After Multiple Imputation by Chained Equations Use
| Mental Status Day t | ||||
|---|---|---|---|---|
| Characteristics on Day t | All ICU Patient-Days (n = 14,013) | Awake Without Delirium (n = 7,961) | Delirium (n = 2,749) | Unarousable Statea (n = 3,303) |
| No pain, n (%) | 4,747 (33.9) | 2,673 (33.6) | 967 (35.2) | 1,107 (33.5) |
| Mild pain, n (%) | 4,146 (29.6) | 2,712 (34.1) | 992 (36.1) | 442 (13.4) |
| Moderate pain, n (%) | 2,328 (16.6) | 1,682 (21.1) | 513 (18.6) | 133 (4.0) |
| Severe pain, n (%) | 1,211 (8.6) | 894 (11.2) | 277 (10.1) | 40 (1.2) |
| Modified Sequential Organ Failure Assessment, median (IQR) | 6 (4–8) | 5 (3–7) | 6 (4–9) | 8 (6–11) |
| Use of invasive mechanical ventilation, n (%) | 11,549 (82.4) | 6,075 (76.3) | 2,302 (83.7) | 3,172 (96.0) |
| Use of a benzodiazepine, n (%) | 4,666 (33.3) | 1,968 (24.7) | 908 (33.0) | 1,790 (54.2) |
| Use of any opioid, n (%) | 9,482 (67.7) | 4,892 (61.4) | 1,808 (65.8) | 2,782 (84.2) |
| Opioid dose (if any) in morphine-equivalent, median (IQR) | 24.0 (7.5–57.9) | 14.7 (5.6–42.0) | 24.7 (7.5–59.9) | 43.4 (22.5–191.5) |
IQR = interquartile range.
a
After Multiple Imputation by Chained Equations was performed, missing pain severity remained in 1,581 of 3,303 days (47.9%) where patient was unarousable.