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| No. of studies (study design) | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Overall certainty of evidence |
|---|---|---|---|---|---|---|
| 6 randomized trials | Not serious | Serious* | Not serious | Very serious† | None | ⨁◯◯◯ |
| VERY LOW |
*Substantial heterogeneity was observed among studies; †Optimal information size was not met (pooled sample size of 300) and confidence intervals were under 0.75 or above 1.25.
