Table 2. Results of laboratory, radiological, and histological evaluation for pediatric acute hepatitis of unknown etiology in Korea.
| Variables | Total (N = 270) | Surveillance (n = 82) | Control (n = 188) | P value | |
|---|---|---|---|---|---|
| AST, U/L | 1,283.53 ± 3,025.67 | 1,782.06 ± 4,864.97 | 1,066.08 ± 1,661.51 | 0.197 | |
| ALT, U/L | 1,255.00 ± 1,626.87 | 1,404.49 ± 2,512.29 | 1,189.80 ± 1,029.22 | 0.457 | |
| TB, mg/dL | 2.70 ± 4.91 | 2.73 ± 4.66 | 2.68 ± 5.03 | 0.944 | |
| DB, mg/dL | 2.59 ± 4.43 | 2.10 ± 3.79 | 2.86 ± 4.75 | 0.254 | |
| Albumin, g/dL | 3.99 ± 1.80 | 3.87 ± 0.60 | 4.05 ± 2.12 | 0.472 | |
| PT-INR | 1.68 ± 4.42 | 1.39 ± 0.89 | 1.81 ± 5.29 | 0.506 | |
| Total WBC, ×103/μL | 9.08 ± 4.81 | 10.07 ± 5.35 | 8.65 ± 4.51 | 0.026* | |
| Platelet, 103/uL | 301.10 ± 140.37 | 286.70 ± 129.96 | 307.34 ± 144.54 | 0.270 | |
| hs-CRP, mg/L | 6.25 ± 22.01 | 9.08 ± 29.39 | 4.95 ± 17.59 | 0.253 | |
| ESR, mm/hr | 14.77 ± 17.21 | 15.33 ± 19.22 | 14.45 ± 16.04 | 0.733 | |
| Liver sonography | 183 (67.8) | 54 (65.9) | 129 (68.6) | 1.000 | |
| Normal | 95 (51.9) | 22 (40.7) | 73 (57) | 0.052 | |
| Hepatosplenomegaly | 41 (22.4) | 13 (24.5) | 28 (21.7) | 0.703 | |
| Gall bladder, duct abnormalitya | 31 (16.9) | 14 (25.9) | 17 (13.2) | 0.051 | |
| Portal edema | 29 (15.8) | 12 (22.2) | 17 (13.2) | 0.182 | |
| Increased echogenicity | 13 (7.1) | 4 (7.4) | 9 (7.0) | 1.000 | |
| Ascites | 15 (8.2) | 9 (17) | 6 (4.7) | 0.014 | |
| Liver CT | 42 (15.6) | 14 (17.1) | 28 (14.9) | 0.597 | |
| Normal | 8 (19) | 2 (14.3) | 6 (23) | 0.697 | |
| Hepatosplenomegaly | 21 (50) | 9 (64.3) | 12 (42.9) | 0.326 | |
| Gall bladder, duct abnormalitya | 16 (38.1) | 5 (35.7) | 11 (39.3) | 1.000 | |
| Portal edema | 22 (52.4) | 7 (50) | 15 (53.6) | 1.000 | |
| Ascites | 18 (42.9) | 5 (35.7) | 13 (46.4) | 0.742 | |
| Liver biopsy | 23 (8.5) | 8 (9.8) | 15 (8.2) | 0.637 | |
| Necrosis | 1 (14.3) | 2 (13.3) | |||
| Intrahepatic cholestasis | 2 (13.3) | ||||
Values are presented as number (%) or mean ± standard deviation.
AST = aspartate transaminase, ALT = alanine transaminase, TB = total bilirubin, DB = direct bilirubin, PT-INR = prothrombin time – international normalized ratio, WBC = white blood cell count, CRP = C-reactive protein, hs-CRP = high-sensitivity C-reactive protein, ESR = erythrocyte sedimentation rate, CT = computed tomography.
aGB wall thickening, GB sludge, and intrahepatic duct dilatation.
*The P value is less than 0.05 in the analysis between the surveillance group (May to November 2022) and control subgroup (May to November 2021).