TABLE 3.

Annualised change in forced vital capacity (FVC) for non-idiopathic pulmonary fibrosis interstitial lung disease (ILD) patients stratified by immunosuppressant (IS) exposure and age-adjusted leukocyte telomere length (LTL) <10th and ≥10th percentile of normal

	IS exposed		IS unexposed		p-value
	n (n FVC)	ΔFVC, mL per year (95% CI) #	n (n FVC)	ΔFVC, mL per year (95% CI) #
LTL <10th percentile	55 (209)	−141 (−218– −65)	56 (177)	−111 (−184– −39)	0.58
LTL ≥10th percentile	231 (978)	−46 (−79– −12)	195 (673)	−76 (−113– −39)	0.23

^#: joint model incorporating time-to-event and linear mixed effects submodels, adjusted for ILD diagnosis, radiographic honeycombing and ILD centre. Restricted to patients with at least two FVC measurements while on immunosuppression within 2 years of blood collection for exposed patients and at least two FVC measurements within 2 years of blood collection for unexposed patients.