Table 1.
The characteristics of breast cancer patients grouped by PAM50
| PAM50 | |||||
|---|---|---|---|---|---|
|
| |||||
| Luminal A (n=148) | Luminal B (n=143) | Her2-enriched (n=54) | Basal-like (n=27) | P-value | |
| Diagnosed age | 0.27 | ||||
| Mean (SD) | 55.8 (11.5) | 58.2 (12.1) | 58.4 (13.3) | 58.3 (10.3) | |
| Median [Min, Max] | 53.5 [33.0, 90.0] | 57.0 [33.0, 93.0] | 58.5 [24.0, 82.0] | 58.0 [40.0, 78.0] | |
| Operation type | 0.46 | ||||
| Breast-conserving surgery | 72 (48.6%) | 70 (49.0%) | 20 (37.0%) | 12 (44.4%) | |
| Modified radical mastectomy | 76 (51.4%) | 73 (51.0%) | 34 (63.0%) | 15 (55.6%) | |
| ER | 5.00E-04 | ||||
| - | 4 (2.7%) | 0 (0%) | 24 (44.4%) | 21 (77.8%) | |
| + | 144 (97.3%) | 143 (100%) | 30 (55.6%) | 6 (22.2%) | |
| PR | 2.50E-23 | ||||
| - | 15 (10.1%) | 15 (10.5%) | 30 (55.6%) | 21 (77.8%) | |
| + | 133 (89.9%) | 128 (89.5%) | 24 (44.4%) | 6 (22.2%) | |
| Her2 | 8.10E-41 | ||||
| - | 144 (97.3%) | 127 (88.8%) | 8 (14.8%) | 24 (88.9%) | |
| + | 4 (2.7%) | 16 (11.2%) | 46 (85.2%) | 3 (11.1%) | |
| Grade | 5.00E-04 | ||||
| 1 | 38 (25.7%) | 5 (3.5%) | 1 (1.9%) | 0 (0%) | |
| 2 | 99 (66.9%) | 81 (56.6%) | 12 (22.2%) | 3 (11.1%) | |
| 3 | 11 (7.4%) | 57 (39.9%) | 41 (75.9%) | 24 (88.9%) | |
| Ki67 | 1.80E-52 | ||||
| Mean (SD) | 12.2 (8.92) | 28.4 (14.7) | 43.1 (18.1) | 54.3 (20.5) | |
| Median [Min, Max] | 10.0 [1.00, 60.0] | 25.0 [5.00, 75.0] | 40.0 [15.0, 80.0] | 60.0 [20.0, 90.0] | |
| Ki67 (cutoff point =14) | 9.20E-33 | ||||
| - | 96 (64.9%) | 13 (9.1%) | 0 (0%) | 0 (0%) | |
| + | 52 (35.1%) | 130 (90.9%) | 54 (100%) | 27 (100%) | |
| Ki67 (cutoff point =20) | 5.20E-30 | ||||
| - | 114 (77.0%) | 35 (24.5%) | 4 (7.4%) | 0 (0%) | |
| + | 34 (23.0%) | 108 (75.5%) | 50 (92.6%) | 27 (100%) | |
| Tumor size | 1.80E-03 | ||||
| Mean (SD) | 1.95 (0.972) | 2.29 (1.09) | 2.49 (1.04) | 2.44 (1.08) | |
| Median [Min, Max] | 1.80 [0.600, 5.80] | 2.10 [0.400, 7.00] | 2.20 [0.700, 5.10] | 2.20 [1.10, 6.00] | |
| Tumor size (cut 2 cm) | 0.012 | ||||
| Small | 84 (56.8%) | 66 (46.2%) | 20 (37.0%) | 8 (29.6%) | |
| Large | 64 (43.2%) | 77 (53.8%) | 34 (63.0%) | 19 (70.4%) | |
| Lymph node number | 0.77 | ||||
| Mean (SD) | 1.72 (5.14) | 1.86 (4.26) | 2.09 (3.48) | 2.70 (5.30) | |
| Median [Min, Max] | 0 [0, 37.0] | 0 [0, 33.0] | 1.00 [0, 15.0] | 0 [0, 24.0] | |
| Lymph node | 0.074 | ||||
| - | 101 (68.2%) | 89 (62.2%) | 26 (48.1%) | 16 (59.3%) | |
| + | 47 (31.8%) | 54 (37.8%) | 28 (51.9%) | 11 (40.7%) | |
| IHC subtypes (Ki67 cutoff point =14) | 5.00E-04 | ||||
| Luminal A-like | 91 (61.5%) | 13 (9.1%) | 0 (0%) | 0 (0%) | |
| Luminal B-like | 53 (35.8%) | 130 (90.9%) | 33 (61.1%) | 9 (33.3%) | |
| Her2-enriched | 1 (0.7%) | 0 (0%) | 18 (33.3%) | 3 (11.1%) | |
| TNBC | 3 (2.0%) | 0 (0%) | 3 (5.6%) | 15 (55.6%) | |