Table 3.
Differentially expressed microRNAs in association with clinical and histopathological parameters in patients with HPV-positive penile squamous cell carcinoma
| miRDE | miRNA Expression | Variables | p-value | Group (p-value) |
|---|---|---|---|---|
| let-7a-5p | Upregulated | Grade | 0.05 | G2 vs. G3 (0.05) |
| miR-200c-3p | Upregulated | Grade | 0.05 | G2 vs. G3 (0.0459) |
| miR-205-5p | Upregulated | Grade | 0.0100 | G2 vs. G3 (0.0073) |
| miR-142-3p | Upregulated | Staging | 0.0126 | pT1 vs. pT2 (0.0257) |
| pT2 vs. pT3 (0.0329) | ||||
| miR-144-3p | Downregulated | Staging | 0.0197 | pT1 vs. pT2 (0.0199) |
| miR-15b-5p | Upregulated | Size | 0.0192 | 2.1-5 vs. 5.1-10 (0.0190) |
| Lesion | 0.0191 | Ulcerated vs. vegetative (0.0371) | ||
| Vegetative vs. verrucous (0.0353) | ||||
| miR-16-5p | Upregulated | Lesion | 0.0202 | Ulcerated vs. vegetative (0.0395) |
| miR-25-3p | Upregulated | Lesion | 0.0386 | Ulcerated vs. vegetative (0.0304) |
| Size | 0.0007 | 0.6-2 vs. 2.1-5 (0.0005) | ||
| 0.6-2 vs. 5.1-10 (0.0160) | ||||
| miR-93-5p | Upregulated | Size | 0.0286 | 0.6-2 vs. 2.1-5 (0.0221) |
| miR-130a-3p | Upregulated | Lesion | 0.0154 | Ulcerated vs. vegetative (0.0111) |
miRDE = microRNAs differentially expressed.