. 2023 Nov 15;13(11):5466–5481.

Table 4.

New target genes potentially regulated by microRNAs differentially expressed in HPV-positive penile squamous cell carcinoma

Gene	miRDE	miRNA Expression	miTG	p-value	Biological consequence
MDM2	miR-661	Downregulated	0.800	0.001	Ubiquitination and degradation of p53
MDM4	miR-433-3p	Downregulated	0.800	0.001	Ubiquitination and degradation of p53
MDM4	miR-661	Downregulated	0.800	0.001	Ubiquitination and degradation of p53
LDLR	miR-130a-3p	Upregulated	0.960	0.001	Deregulation of cholesterol metabolism
HSPA1B	miR-142-3p	Upregulated	0.802	0.001	Protein instability
VPS37C	miR-15b-5p	Upregulated	0.850	0.001	ESCRT-I (endosomal sorting complex required for transport I) dysregulation
VPS37C	miR-16-5p	Upregulated	0.859	0.001
CHMP2B	miR-200c-3p	Upregulated	0.812	0.001	ESCRT-III (endosomal sorting complex required for transport III) dysregulation
DDX3X	miR-15b-5p	Upregulated	0.992	0.002	Loss of expression induces resistance to chemotherapy, while its expression is related to viral replication
	miR-16-5p	Upregulated	0.993
	miR-25-3p	Upregulated	0.869
	miR-495-3p	Downregulated	1.000
PTEN	miR-22-3p	Upregulated	0.911	0.002	Inhibition of apoptosis and induction of cell proliferation and growth
	miR-205-5p	Upregulated	0.937
	miR-130a-3p	Upregulated	0.861
IKBKB	miR-15b-5p	Upregulated	0.861	0.008	Inhibition of apoptosis and increased cell survival
IKBKB	miR-16-5p	Upregulated	0.892	0.008	Inhibition of apoptosis and increased cell survival
PRDM4	miR-15b-5p	Upregulated	1.000	0.008	Cell cycle progression, activation of PI3K/AKT signaling and PTEN inhibition
PRDM4	miR-16-5p	Upregulated	1.000	0.008
WASL	mir-130a-3p	Upregulated	0.919	0.007	Destabilization of the cytoskeleton
MET	miR-144-3p	Downregulated	0.800	0.007	Increased cell survival and induction of cell migration and invasion.
MET	miR-433-3p	Downregulated	0.800	0.007

miRDE = microRNA Differentially Expressed; miTG = microRNA Target Gene; hrHPV = high-risk Human Papilloma Virus.