Table 2.

Univariate and multivariate analyses of overall survival in MSKCC cohort

Parameter	Univariate analysis			Multivariate analysis
	HR	95% CI	P value	HR	95% CI	P value
Sex
Male vs. Female	0.517	0.283-0.942	0.031	0.441	0.239-0.817	0.009
Age
> 60 vs. ≤ 60	0.506	0.255-1.003	0.051
RNF43 gene
MUT vs. WT	0.122	0.032-0.552	0.006	0.128	0.025-0.747	0.022
Tumor location
Rectum vs. others	0.858	0.337-2.185	0.748
Drug type
PD-L1/1 vs. others	0.992	0.305-3.224	0.989
TMB status
> median vs. ≤ median	0.628	0.340-1.158	0.136
MSI status
MSI-H vs. MSS	0.264	0.103-0.678	0.006	0.716	0.244-2.104	0.544