Figure 2.

Elevated OTUB2 predicts a poor prognosis for colorectal cancer patients. (A) The expression of OTUB2 in colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) analyzed by GEPIA matched with TCGA normal and GTEx data (http://gepia2.cancer-pku.cn). The red boxes represent the tumor tissues; the gray boxes represent the normal tissues. *P<0.01. (B) Twenty pairs of para-cancerous and cancerous tissues of colorectal cancer (CRC) were prepared for qRT-PCR to detect the mRNA levels of OTUB2. **P<0.01. (C and D) The tissue chips embedding 169 CRC para-cancerous and cancerous tissues were prepared for immunohistochemical analysis of OTUB2, and the immunohistochemical scores were calculated (C). The representative images of immunohistochemistry (D). ***P<0.001. (E) Survival curve analysis based on immunohistochemistry results.