Table 2.
Cardiac magnetic resonance (CMR) and Histological data of all subjects.
| baseline |
4 weeks |
6 weeks |
8 weeks |
12 weeks |
16 weeks |
|
|---|---|---|---|---|---|---|
| (n = 34) | (n = 25) | (n = 19) | (n = 12) | (n = 7) | (n = 3) | |
| CMR date | ||||||
| LVEF, % | 53.4 ± 3.2 | 52.3 ± 2.7 | 52.2 ± 2.1 | 51.9 ± 1.7 | 49.0 ± 2.6a | 47.7 ± 0.8a |
| Myocardium Native T1 value, ms | 1396.5 ± 79.2 | 1469.4 ± 67.5a | 1480.2 ± 69.9a | 1498.8 ± 95.4a | 1460.6 ± 75.6 | 1445.3 ± 60.9 |
| Myocardium T2 value, ms | 36.6 ± 3.3 | 37.5 ± 3.4a | 40.1 ± 2.5a | 40.1 ± 1.9a | 41.1 ± 1.7a | 42.8 ± 0.3a |
| ECV, % | 30.2 ± 2.5 | 31.8 ± 2.3 | 32.2 ± 3.5 | 33.9 ± 3.8a | 34.2 ± 1.8a | 36.5 ± 1.1a |
| Histological data | ||||||
| Edema score | 0.0 ± 0.0 | 0.8 ± 0.3 | 0.9 ± 0.4 | 1.2 ± 0.8 | 1.8 ± 1.0a | 1.6 ± 0.4 |
| CVF, % | 2.0 ± 0.2 | 2.6 ± 0.8 | 2.6 ± 0.5 | 3.6 ± 0.6 | 5.3 ± 0.5a | 7.8 ± 1.1a |
| MVD, number | 19.0 ± 8.5 | 12.8 ± 4.2 | 12.5 ± 0.7 | 12.5 ± 4.7 | 7.3 ± 3.2 | 10.0 ± 4.4 |
LVEF:left ventricular ejection fraction; ECV:extracellular volume fraction.CVF:collagen volume fractions; MVD:Microvascular density.
a
Indicated p < 0.050. All data are expressed as mean ± SD.