. 2023 Oct 9;31(1):262–271. doi: 10.1245/s10434-023-14402-6

Table 4.

Uni- and multivariate analyses of prognostic factors for overall survival

	Univariate analysis			Multivariate analysis
	HR	95 % CI	P value	HR	95 % CI	P value
Sex (male vs female)	1.030	0.581–1.823	0.921
Age (> 60 vs ≤ 60 years)	1.426	0.926–2.196	0.107
HBV (positive vs negative)	0.873	0.569–1.339	0.533
HCV (positive vs negative)	1.132	0.743–1.724	0.565
Albumin (< 4 vs ≥ 4 g/dl)	1.826	1.204–2.770	0.005^a	1.565	1.000–2.452	0.050^a
AFP (> 10 vs ≤ 10 ng/ml)	1.668	1.090–2.553	0.018^a	1.416	0.899–2.227	0.133
PIVKAII (> 40 vs ≤ 40 mAU/ml)	1.570	1.002–2.459	0.049^a	1.445	0.867–2.408	0.157
Tumor number (multiple vs one)	1.824	1.134–2.932	0.013^a	1.931	1.170–3.186	0.010^a
Tumor size (> 5 vs ≤ 5 cm)	2.110	1.384–3.218	0.001^a	1.854	1.114–3.085	0.017^a
Vascular invasion (positive vs. negative)	2.630	1.645–4.205	< 0.001^a	2.291	1.340–3.915	0.002^a
Differentiation (poor vs well-moderate)	1.361	0.826–2.241	0.226
Non-cancerous liver (cirrhosis vs. no cirrhosis)	1.721	1.130–2.623	0.012^a	1.755	1.116–2.761	0.014^a
Wnt5a−ROR2−
vs Wnt5a−ROR2+	1.249	0.790–1.974	0.339	1.264	0.770–2.077	0.353
vs Wnt5a+ROR2−	2.258	0.877–9.310	0.081	2.869	0.855–9.624	0.087
vs Wnt5a+ROR2+	2.028	1.049–3.918	0.035^a	2.058	1.013–4.180	0.045^a

HR hazard ratio, CI confidence interval, HBV hepatitis B virus, HCV hepatitis C virus, NBNC non-hepatitis B virus and non-hepatitis C virus, AFP α-fetoprotein, PIVKAII protein induced by vitamin K absence or antagonist II

^aP < 0.05