Table 2.
Baseline characteristics stratified according to fibrosis
| Fibrosis | All (n = 399) n (%) | No fibrosis (n = 92) n (%) | Periportal fibrosis (n = 150) n (%) | Septal fibrosis (n = 123) n (%) | Biliary cirrhosis (n = 34) n (%) | p Value |
|---|---|---|---|---|---|---|
| Median age: years (IQR) | 65 (57–71) | 65 (56–71) | 66 (58–72) | 65 (57–71) | 63 (58–72) | 0.943 |
| Male sex | 252 (63) | 52 (57) | 86 (57) | 90 (74) | 24 (71) | 0.014 |
| Median BMI: kg/m2 (IQR) | 25 (22.5–26.7) | 24.7 (22.4–26.6) | 24.5 (22.1–27.3) | 25.3 (23–26.5) | 25 (22.9–27) | 0.216 |
| ASA | ||||||
| I | 56 (14) | 17 (19) | 18 (12) | 17 (14) | 4 (12) | 0.025 |
| II | 209 (53) | 38 (41) | 81 (54) | 64 (53) | 26 (79) | |
| III | 125 (32) | 34 (37) | 48 (32) | 40 (33) | 3 (9) | |
| IV | 6 (2) | 3 (3) | 3 (2) | 0 (–) | 0 (–) | |
| Jaundice at presentation | 300 (75) | 70 (77) | 111 (74) | 94 (76) | 25 (74) | 0.939 |
| Biliary drainage (ERCP, PTC, or both) | 338 (85) | 76 (83) | 128 85) | 106 (87) | 28 (85) | 0.858 |
| Preoperative cholangitis | 155 (39) | 32 (35) | 56 (38) | 52 (43) | 15 (46) | 0.560 |
| PVE performed | 104 (26) | 25 (27) | 48 (32) | 29 (24) | 2 (6) | 0.018 |
| FLR below 40 % | 132 (37) | 36 (45) | 47 (34) | 43 (39) | 6 (20) | 0.088 |
| Surgery | ||||||
| Left hemihepatectomy | 108 (27) | 22 (24) | 41 (27) | 29 (24) | 16 (47) | 0.234 |
| Extended left hemihepatectomy | 62 (16) | 17 (19) | 22 (15) | 21 (17) | 2 (6) | |
| Right hemihepatectomy | 79 (20) | 17 (19) | 28 (19) | 25 (20) | 9 (27) | |
| Extended right hemihepatectomy | 146 (37) | 36 (39) | 56 (37) | 47 (38) | 7 (21) | |
| Central/mesohepatectomy | 4 (1) | 0 (–) | 2 (2) | 1 (1) | 0 (–) | |
| PV reconstruction | 196 (50) | 56 (61) | 77 (52) | 52 (43) | 11 (32) | 0.011 |
| HA reconstruction | 18 (5) | 7 (8) | 3 (2) | 8 (7) | 0 (–) | 0.073 |
| Complete resection (R0) | 291 (76) | 74 (84) | 111 (76) | 86 (74) | 20 (63) | 0.080 |
| ISGLS liver failure (grade B/C) | 62 (16) | 17 (19) | 18 (12) | 23 (19) | 4 (12) | 0.353 |
| 30-Day mortality | 52 (15) | 15 (20) | 13 (10) | 18 (16) | 6 (18) | 0.223 |
| 90-Day mortality | 67 (17) | 21 (23) | 17 (11) | 21 (17) | 8 (24) | 0.082 |
IQR interquartile range, BMI body mass index, ASA American Society of Anesthesiologists, ERCP endoscopic retrograde cholangiopancreatography, PTC percutaneous transhepatic cholangiography, PVE portal vein embolization, FLR future liver remnant, PV portal vein, HA hepatic artery, ISGLS International Study Group of Liver Surgery