Table 2.

Odds ratio of overuse bilateral mastectomy and underuse of RT

GGT result	Bilateral mastectomya			Radiation therapyb
	N (%)	Odds ratio	95% confidence interval	N (%)	Odds ratio	95% confidence interval
Negative	12/103 (11.7)	1 (Reference)		12/78 (15.4)	1 (Reference)
BRCA1/BRCA2 PGV	3/3 (100)	51.24	2.5–1051.66	NA	NA	NA
Other PGV	2/15 (13.3)	1.17	0.23–5.81	1/10 (10.0)	0.61	0.07–5.28
VUS	4/35 (11.4)	0.98	0.29–3.26	3/27 (11.1)	0.69	0.18–2.65

Data are numbers with percentages in parentheses unless otherwise indicated

RT radiotherapy, GGT germline-genetic testing, PGV pathogenic germline variants, VUS variant of uncertain significance, NA not applicable

^aEligible cases were patients who had stage 0–III breast cancer

^bEligible cases were patients who had stage 0–III breast cancer that underwent breast-conserving therapy, excluding patients > 70 years of age with stage I, estrogen receptor- and/or progesterone receptor-positive/ERBB2-negative tumors as defined in Kurian et al.³⁵