. 2023 Oct 9;31(1):325–334. doi: 10.1245/s10434-023-14394-3

Table 3.

Genetics-informed changes in radiation therapy strategy

	Overall n = 185	PGV-positive n = 25	VUS n = 46	Negative n = 121	PGV versus VUS/negative, p
Total w/change in RT strategy (% of all pts tested)	103 (55.7)	15 (60.0)	21 (45.7)	67 (55.4)	–
APBI or AWBI (%)^a	81 (76.7)	2 (13.3)	18 (85.7)	61 (91.0)	> 0.001
Omission of RT (%)^a	9 (8.7)	2 (13.3)	1 (4.8)	6 (9.0)	0.664
Conventional/standard fractionation (%)^a	13 (12.6)	11 (73.3)	2 (9.5)	0 (0.0)	> 0.001

APBI accelerated partial breast irradiation, AWBI accelerated whole breast irradiation, PGV pathogenic germline variants, RT radiotherapy

^a% of pts with change in RT strategy