Table 2.
Univariate and multivariable analysis of recurrence-free survival
| Univariate analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|
| Item | HR (95% CI) | p-value (Wald’s test) | p-value (LR test) | Adj. HR 95% CI | Adj. p-value |
| Sex: male versus Female | 0.67 (0.35, 1.29) | 0.233 | 0.209 | ||
| Age: < 65 versus ≥ 65 years | 1.12 (0.73, 1.71) | 0.615 | 0.618 | ||
| Smoker: yes versus no | 1.08 (0.7, 1.68) | 0.728 | 0.727 | ||
| Drinker: yes versus no | 1.17 (0.75, 1.81) | 0.49 | 0.486 | ||
| Location: ref. Up | 0.211 | ||||
| Middle | 1.75 (0.88, 3.48) | 0.112 | |||
| Low | 1.37 (0.69, 2.74) | 0.368 | |||
| Differentiation: ref. well | < 0.001 | 1.4 (0.88~2.24) | 0.157 | ||
| Middle | 12.77 (1.76, 92.75) | 0.012 | |||
| Poor | 12.19 (1.68, 88.58) | 0.013 | |||
| Surgical margin: positive versus negative | 1.78 (0.44, 7.24) | 0.42 | 0.460 | ||
| Nerve Invasion: positive versus negative | 2.22 (1.42, 3.47) | < 0.001 | 0.001 | 2.05 (0.73~5.81)) | 0.175 |
| Lymph vascular invasion: positive versus negative | 2.75 (1.61, 4.72) | < 0.001 | < 0.001 | 2.36 (0.94~5.89) | 0.067 |
| cT: ref. 2 | 0.392 | ||||
| 3 | 0.81 (0.39, 1.68) | 0.567 | |||
| 4a | 0.67 (0.25, 1.78) | 0.416 | |||
| 4b | 1.36 (0.55, 3.39) | 0.507 | |||
| cN: ref. 0 | 0.288 | ||||
| 1 | 0.89 (0.27, 2.92) | 0.85 | |||
| 2 | 0.79 (0.24, 2.55) | 0.694 | |||
| 3 | 1.43 (0.42, 4.94) | 0.57 | |||
| ypT: ref. 0 | 0.016 | 1.03(0.51~2.1) | 0.929 | ||
| 1 | 1.4 (0.76, 2.6) | 0.285 | |||
| 2 | 0.81 (0.41, 1.57) | 0.531 | |||
| 3 | 1.9 (1.17, 3.09) | 0.009 | |||
| 4 | 3.49 (1.06, 11.44) | 0.039 | |||
| ypN: ref. 0 | < 0.001 | 0.81 (0.34~1.93) | 0.634 | ||
| 1 | 1.99 (1.26, 3.14) | 0.003 | |||
| 2 | 2.86 (1.6, 5.1) | < 0.001 | |||
| 3 | 5.47 (0.75, 40) | 0.094 | |||
| AJCC/TNM stage: ref. 0 | 0.002 | 1.58 (0.17~14.33) | 0.683 | ||
| I | 0.87 (0.46, 1.67) | 0.682 | |||
| II | 1.26 (0.63, 2.54) | 0.517 | |||
| III | 2.27 (1.37, 3.77) | 0.002 | |||
| IV | 3.37 (1.01, 11.27) | 0.048 | |||
| pCR: yes versus no | 1.57 (0.98, 2.51) | 0.06 | 0.051 | 0.1 (0.01~0.86) | 0.036 |
| PT–TRG: ref. 0 | 0.024 | 0.73 (0.34~1.6) | 0.435 | ||
| 1 | 0.9966 (0.56, 1.75) | 0.991 | |||
| 2 | 1.63 (1, 2.66) | 0.048 | |||
| 3 | 2.55 (1.28, 5.07) | 0.008 | |||
| LN–TRG: 0–2 versus 3–4 | 2.97(1.97, 4.48) | < 0.001 | < 0.001 | 3.62 (1.03~12.74) | 0.045 |
| Total carcinoma diameter (lymph node) (cont. var.) | 2.71 (1.6~4.58) | < 0.001 | < 0.001 | 1.95 (0.82~4.62) | 0.129 |
| Number of lymph nodes dissected (cont. var.) | 0.9962 (0.9714, 1.0215) | 0.765 | 0.764 | ||
| WBC grade: 0–2 versus 3–4 | 1.15 (0.76, 1.75) | 0.514 | 0.517 | ||
| Hb grade: 0–2 versus 3–4 | 1.99 (0.27, 14.34) | 0.497 | 0.54 | ||
| Platelet grade: 0–2 versus 3–4 | 5.25 (1.92, 14.33) | 0.001 | 0.01 | 2.5 (0.4~15.69) | 0.327 |
| Neutrophil grade: 0–2 versus 3–4 | 1.23 (0.8, 1.89) | 0.349 | 0.355 | ||
| Myelosuppression grade: 0–2 versus 3–4 | 1.11 (0.73, 1.68) | 0.617 | 0.619 | ||
Bold indicates that the difference is statistically significant