Table 2.

Top 15 PRS models associated with SSQ12 (N = 255)

PRS ID	Reported trait	Beta	p	Adj p	Adj R2
PGS002597	HDL cholesterol	0.42	1.82E-05	0.044*	0.08
PGS002548	HDL cholesterol	0.40	5.49E-05	0.044*	0.08
PGS002695	HDL cholesterol	0.39	6.88E-05	0.044*	0.07
PGS000845	HDL cholesterol	0.40	8.53E-05	0.044*	0.07
PGS000064	HDL cholesterol	0.39	0.0001	0.050	0.07
PGS002101	Apolipoprotein A	0.37	0.0001	0.063	0.07
PGS002329	HDL cholesterol	0.36	0.0003	0.11	0.06
PGS002172	HDL cholesterol	0.35	0.0003	0.11	0.06
PGS001888	Apolipoprotein A	0.34	0.0004	0.12	0.06
PGS000777	Parkinson’s disease dementia	− 0.33	0.0005	0.13	0.06
PGS000309	High-density lipoprotein	0.34	0.0006	0.14	0.06
PGS000695	Sodium in urine (mmol/L)	0.36	0.0008	0.17	0.06
PGS002401	HDL cholesterol	0.34	0.0012	0.22	0.05
PGS001586	Volume of grey matter in parahippocampal gyrus, posterior division (R)	0.33	0.0013	0.24	0.05
PGS002112	Recent feelings of depression	− 0.31	0.0020	0.33	0.05

Baseline model 1 (predictors: age, sex, ethnicity): adjusted R² = 0.018, p = 0.054 (age was a significant predictor)

Baseline model 2 (predictors: age, sex, ethnicity, PCA1-5): adjusted R² = 0.02, p = 0.09 (Age and PCA5 were significantly associated with SSQ12)