Table 3.

Top 15 PRS models associated with PTA_4-8 (N = 218)

PRS ID	Reported trait	Beta	p	Adj p	Adj R2
PGS001347	Family history of Alzheimer’s/dementia	2.15	3.55E-05	0.046*	0.05
PGS000929	All cause dementia (algorithmically-defined)	2.07	7.03E-05	0.046*	0.04
PGS002035	Dementias	2.08	7.07E-05	0.046*	0.04
PGS001349	Alzheimer’s disease (time-to-event)	1.98	0.0001	0.071	0.04
PGS001348	Alzheimer’s disease (algorithmically-defined)	1.94	0.0001	0.07	0.03
PGS001179	Vascular dementia (time-to-event)	1.93	0.0002	0.07	0.03
PGS001827	Dementias	1.90	0.0002	0.07	0.03
PGS000946	Unspecified dementia (time-to-event)	1.89	0.0002	0.07	0.03
PGS001828	Alzheimer’s disease	1.89	0.0002	0.07	0.03
PGS002289	Late-onset Alzheimer’s disease	1.93	0.0003	0.07	0.03
PGS000945	Dementia in Alzheimer's disease (time-to-event)	1.79	0.0004	0.10	0.02
PGS000779	Alzheimer’s disease	1.83	0.0009	0.18	0.02
PGS001710	WA L1 in tract superior longitudinal fasciculus (R)	− 1.86	0.001	0.21	0.02
PGS000334	Late-onset Alzheimer’s disease	1.71	0.001	0.21	0.02
PGS001263	Atrial flutter	1.87	0.002	0.37	0.01

Baseline model 1 (predictors: age, sex, ethnicity): adjusted R² =  − 0.005, p > 0.05 (no predictors achieved statistical significance)

Baseline model 2 (predictors: age, sex, ethnicity, PCA1-5): adjusted R² =  − 0.02, p > 0.05 (no predictors achieved statistical significance)