Table 4.

Top 15 PRS models associated with PTA_12-16 (N = 218)

PRS name	Reported trait	Beta	p	Adj p	Adj R2
PGS001339	Atrial fibrillation and flutter (time-to-event)	5.01	1.8E-07	0.0003**	0.12
PGS001340	Atrial fibrillation	5.10	2.5E-07	0.0003**	0.12
PGS001263	Atrial flutter	4.96	3.9E-07	0.0003**	0.11
PGS002050	Atrial fibrillation and flutter	4.14	2.4E-05	0.015*	0.08
PGS000331	Atrial fibrillation	4.03	3.4E-05	0.017*	0.07
PGS001841	Atrial fibrillation and flutter	4.00	4.9E-05	0.021*	0.07
PGS000016	Atrial fibrillation	4.14	9.4E-05	0.035*	0.07
PGS002294	Breast cancer	3.20	0.001	0.32	0.05
PGS001947	Cystatin C	− 2.94	0.001	0.36	0.04
PGS000035	Atrial fibrillation	2.95	0.001	0.42	0.04
PGS000228	Cathepsin L1 (CTSL1) serum levels	2.82	0.001	0.42	0.04
PGS000338	Atrial fibrillation	2.85	0.002	0.44	0.04
PGS000050	Breast cancer	2.57	0.002	0.48	0.04
PGS001356	Atrial fibrillation	− 3.01	0.002	0.48	0.04
PGS002165	Cystatin C	− 2.84	0.002	0.48	0.04

Baseline model 1 (predictors: age, sex, ethnicity): adjusted R² = 0.01, p > 0.05 (no predictors achieved statistical significance)

Baseline model 2 (predictors: age, sex, ethnicity, PCA1-5): adjusted R² = 0.002, p > 0.05 (no predictors achieved statistical significance)

*p < 0.05, **p < 0.001