Table 2.
The BMP family members and their receptors
| Ligand | Type I receptor | Type II receptor | Co-receptor |
|---|---|---|---|
| BMP2 | BMPR1A, BMPR1B | ACVR2, ACVR2B, BMPR2 | RGM |
| BMP4 | BMPR1A, BMPR1B | ACVR2, ACVR2B, BMPR2 | |
| BMP5 | ACVR1A, BMPR1A, BMPR1B | ACVR2, ACVR2B, BMPR2 | |
| BMP6 | ACVR1A, BMPR1A, BMPR1B | ACVR2, ACVR2B, BMPR2 | RGM |
| BMP7 | ACVR1A, BMPR1A, BMPR1B | ACVR2, ACVR2B, BMPR2 | |
| BMP8 | ACVR1A, BMPR1A, BMPR1B | ACVR2, ACVR2B, BMPR2 | |
| BMP9 | ALK1 | ACVR2, BMPR2 | Endoglin |
| BMP10 | ALK1 | ACVR2, BMPR2 | Endoglin |
| BMP15 | BMPR1B | BMPR2 | |
| BMP3a | - | - | |
| BMP3B | - | - | |
| GDF5 | BMPR1A, BMPR1B | ACVR2, ACVR2B, BMPR2 | |
| GDF6 | BMPR1A, BMPR1B | ACVR2, ACVR2B, BMPR2 | |
| GDF7 | BMPR1A, BMPR1B | ACVR2, ACVR2B, BMPR2 | |
| AMH | ACVR1A, BMPR1A | AMHR2 | |
| GDF15 | GFRALb |
BMP Bone morphogenetic protein, BMPR Bone morphogenic protein receptor, ACVR Activin receptor, RGM Repulsion guidance molecules, GDF Growth and differentiation factor, AMH Anti-Muellerian hormone, AMHR Anti-Muellerian hormone receptor; -, not applicable. aBMP3 antagonizes other BMPs. bGDF15 is a distant member of the TGF-β and BMP family. It signals through a receptor called glial-derived neurotrophic factor receptor alpha-like (GFRAL)