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. 2023 Dec 4;4:46. doi: 10.1186/s43556-023-00156-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — The structural features of Class A GPCRs. a Hallmark for Class A GPCR activation. The cytoplasmic region of TM6 moves outward during receptor activation. b The “push-pull” activation model of the glycoprotein hormone receptor subfamily. c The ECL2 region acts as a “built-in” agonist for GPR52 (PDB: 6LI2). d The N-terminus, ECL2 and ECL3 contribute to the activation of OR51E2 (PDB: 8F76)