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. 2023 Nov 12;9(11):e22204. doi: 10.1016/j.heliyon.2023.e22204

Table 4.

Prediction of top-ranked 30 MHC-II alleles for desired epitopes.


MHC-II Allele		 Position Core Sequence Peptide Sequence IC50 value Rank Antigenicity Score Toxicity Hydroph0bicity Hydrophilicity Mutation Prediction Charge SVM score Molecular weight Allergenicity
AllerTOP
2.0		 AllergenFP
1.0
HLA-DRB1*04:05 144–158 YIHSANVLH RGLKYIHSANVLHRD 6.70 0.01 0.4749 No −0.29 0.12 No 3.00 −0.98 1779.26 Yes No
HLA-DRB1*04:05 145–159 GLKYIHSANVLHRDL 6.80 0.01 0.2509 No −0.13 −0.20 No 2.00 −0.98 1736 No No
HLA-DRB1*04:05 146–160 LKYIHSANVLHRDLK 7.60 0.01 0.5898 No −0.22 0.00 No 3.00 −1.08 1807.36 No No
HLA-DRB3*02:02 269–283 YLLSLPLRS ARNYLLSLPLRSKVP 9.00 0.45 0.4488 No −0.20 −0.11 No 3.00 −1.29 1727.30 No No
HLA-DRB5*01:01 268–282 KARNYLLSLPLRSKV 8.10 0.77 0.6047 No −0.27 −0.09 No 4.00 −1.30 1758.36 No No
HLA-DPA1*03:01/DPB1*04:02 344–358 TLKELIFEX LDDLPKETLKELIFE 959.3 31.0 0.3343 No −0.15 −0.61 No −3.00 −1.77 1803.31 No No
HLA-DPA1*02:01/DPB1*01:01 299–313 MLTFNPHK LDKMLTFNPHKRIEV 1069 31.0 0.8176 No −0.23 0.24 No 1.50 −1.43 1841.43 Yes No
HLA-DQA1*01:02/DQB1*06:02 225–339 AEMLSNRPI CILAEMLSNRPIFPG 962.7 31.0 0.3552 No 0.03 −0.40 No 0.00 −0.90 1661.23 Yes No
HLA-DRB1*11:01 56–70 VRVAIKKIS NKVRVAIKKISPFEH 3.40 0.02 0.4654 No −0.24 0.36 No 3.50 −1.16 1766.36 No No
HLA-DRB1*04:05 147–161 YIHSANVLH KYIHSANVLHRDLKP 13.20 0.07 0.4161 No −0.26 0.12 No 3.00 −0.99 1791.31 No No
HLA-DRB1*12:01 260–274 IINIKARNY DLNCIINIKARNYLL 15.70 0.08 1.0557 No −0.09 −0.33 No 1.00 −0.58 1776.36 No No
HLA-DRB1*12:01 261–275 LNCIINIKARNYLLS 16.50 0.1 0.9209 No −0.06 −0.51 No 2.00 −0.61 1748.35 No No
HLA-DRB1*12:01 269–273 EDLNCIINIKARNYL 18.20 0.01 1.0401 No −0.17 −0.01 No 0.00 −0.45 1792.31 No No
HLA-DRB1*12:01 262–276 NCIINIKARNYLLSL 19.30 0.11 0.8983 No −0.06 −0.51 No 2.00 −0.52 1748.35 No No
HLA-DRB1*12:01 258–272 QEDLNCIINIKARNY 22.90 0.13 1.0882 No −0.25 0.12 No 0.00 −0.03 1807.28 Yes No
HLA-DRB1*12:01 263–277 CIINIKARNYLLSLP 24.90 0.15 0.7558 No −0.03 −0.53 No 2.00 −0.83 1731.36 No No
HLA-DRB4*01:01 120–134 LLKTQHLSN DLYKLLKTQHLSNDH 14.00 0.25 0.9376 No −0.27 0.12 No 1.00 −0.90 1825.75 No No
HLA-DRB4*01:01 21–35 LYKLLKTQHLSNDHI 13.50 0.23 −0.6296 No −0.17 −0.20 No 2.00 −0.93 1823.37 No No
HLA-DRB1*11:01 57–71 VRVAIKKIS KVRVAIKKISPFEHQ 5.80 0.25 0.2936 No −0.25 0.36 No 3.50 −1.31 780.37 No Yes
HLA-DRB1*11:01 53–67 DRDNKVRVAIKKISP 4.90 0.18 0.6534 No −0.43 0.96 No 3.00 −1.34 1739.26 Yes No
HLA-DRB1*11:01 54–68 RDNKVRVAIKKISPF 3.90 0.11 0.6600 No −0.34 0.59 No 4.00 −1.30 1771.35 No No
HLA-DRB1*11:01 55–69 DNKVRVAIKKISPFE 3.80 0.09 0.5399 No −0.26 0.59 No 2.00 −1.28 1744.28 No No
HLA-DRB1*01:01 268–282 YLLSLPLRS KARNYLLSLPLRSKV 3.30 0.09 0.6047 No −0.27 0.09 No 4.00 −1.30 1758.36 No Yes
HLA-DRB1*01:01 269–283 ARNYLLSLPLRSKVP 3.50 0.11 0.4485 No −0.20 −0.11 No 3.00 −1.29 1727.30 No No
HLA-DRB1*01:01 270–284 RNYLLSLPLRSKVPW 3.80 0.14 0.1028 No −0.19 −0.31 No 3.00 −.12 1842.44 No No
HLA-DRB1*04:05 118–132 YKLLKTQH ETDLYKLLKTQHLSN 16.20 0.13 1.0167 No −0.25 0.13 No 0.50 −1.05 1803.23 No No
HLA-DRB1*04:05 119–133 TDLYKLLKTQHLSND 16.90 0.14 0.9217 No −0.26 0.13 No 0.50 −0.88 1789.25 No No
HLA-DRB1*04:05 117–131 METDLYKLLKTQHLS 17.40 0.15 0.9272 No −0.19 0.03 No 0.50 −1.15 1820.37 No No
HLA-DRB1*12:01 137–151 YQILRGLKY YFLYQILRGLKYIHS 25.30 0.16 0.5531 No −0.02 −0.83 No 2.50 −0.66 1914.52 No No
HLA-DRB1*12:01 136–150 CYFLYQILRGLKYIH 2.70 0.17 0.6318 No 0.00 −0.91 No 2.50 −0.42 1930.58 Yes No