TABLE 1.
Numbers and frequencies of wild-type and SAFB1 mutant pups in litters of SAFB1+/− intercrosses in 01BA3 and 5F5 lines
| Line and no. of offspring | No. that were:
|
+/+:+/−:−/− ratio |
P value based on:
|
|||
|---|---|---|---|---|---|---|
| +/+ | +/− | −/− | Chi-square testa | Likelihood ratio testb | ||
| O1BA3 | ||||||
| Total, 816 | 323 | 431 | 62 | 1:1.3:0.19 | <0.0001 | |
| Females, 430 | 180 | 223 | 27 | 1:1.2:0.15 | <0.0001 | 0.180 |
| Males, 386 | 143 | 208 | 35 | 1:1.5:0.24 | <0.0001 | |
| 5F5 | ||||||
| Total, 638 | 250 | 347 | 41 | 1:1.4:0.16 | <0.0001 | |
| Females, 318 | 134 | 163 | 21 | 1:1.2:0.16 | <0.0001 | 0.274 |
| Males, 320 | 116 | 184 | 20 | 1:1.6:0.17 | <0.0001 | |
a
Chi-square test for goodness of fit to compare the observed distribution of genotypes with the Mendelian 1:2:1 ratio.
b
Likelihood ratio test comparing distribution of genotype between females versus males from a log-linear model.