TABLE 2.

Two different time points of lethality in SAFB1^−/− mice^a

Time of development	Observed no. of SAFB1−/− mice total no.	Ratio of SAFB1−/− mice to total no.	P valueb (exact 95% CI)
E10.5	8/48	0.167	0.238 (0.07, 0.30)
E11.5-16.5	15/87	0.172	0.114 (0.10, 0.27)
E18.5	5/34	0.147	0.228 (0.05, 0.31)
1 dpp	18/114	0.158	0.025 (0.10, 0.24)
4-6 dpp	2/51	0.039	0.0001 (0.005, 0.13)

^aEmbryos (E10.5 to E18.5) and newborn pups (1 to 6 dpp) were genotyped, and the number of SAFB1^−/− mice is listed in relation to the total number of mice analyzed at each time point.

^bCalculations of P values were based on the exact test for goodness of fit to compare the observed distribution of the SAFB1^−/− genotype with the expected Mendelian ratio of 0.25. CI, confidence interval.