TABLE 3.

Infertility in SAFB1^−/− males and subfertility in SAFB1^−/− females^a

Genotype (males × females)	No. of males	No. of females	No. (%) of pregnant females	P value (Fisher’s exact test)b	Avg no. of pups/litter ± SD	P value (t test)c
+/+ × +/+	2	5	5 (100)		5.6 ± 1.52
+/− × +/+	6	11	10 (91)	0.99	6.1 ± 1.70	0.999
−/− × +/+	7	13	0	0.0005	NAd
+/+ × +/−	5	11	11 (100)		6.4 ± 1.86	0.999
+/+ × −/−	3	14	5 (36)	0.032	3.2 ± 0.45	0.086

^aBreeding pairs were set up as indicated. The proportion of pregnant females was statistically significantly lower in the −/− × +/+ or +/+ × −/− genotype compared to the +/+ × +/+ breeding pairs (p = 0.0005 and 0.032, respectively). (A P value cannot be generated when comparing the +/+ × +/− breeding pair to the wild-type breeding pair since all of the females in this group were pregnant and therefore there is no distribution of pregnant versus nonpregnant in both comparison groups.) There was an indication of a reduction in the average number of pups from the +/+ × −/− compared to the +/+ × +/+ breeding pair. This comparison did not achieve statistical significance because of the small numbers.

^bP value from Fisher's exact test for comparisons with the +/+ × +/+ breeding pair.

^cP value from a two-sample t test with Holm's adjustment for multiple comparisons with the +/+ × +/+ breeding pair.

^dNA, not applicable.