TABLE 1.
Interaction partners of class II HDACs
| Deacetylase | Partner | Function | Reference(s) |
|---|---|---|---|
| Yeast Hda1 | Hda2 | Subunit of the Hda1 complex | 146 |
| Hda3 | Subunit of the Hda1 complex | 146 | |
| TUP1 | Repressor of genes expressed for mating and glucose and oxygen utilization, as well as DNA damage and osmotic stress responses | 147 | |
| Class IIa HDACs | 14-3-3 | Phosphoserine/threonine binding proteins | 54, 76, 100, 140, 161 |
| Calmodulin | Calcium-binding protein | 7, 154 | |
| MEF2 | Regulation of cell differentiation, death, and survival | 76, 93, 104, 135, 139 | |
| SRF | Serum response factor controlling cell growth and differentiation | 29 | |
| Myocardin | Transcriptional coactivator essential for smooth muscle differentiation | 15 | |
| NF-AT3c | Transcription factor required for cell differentiation and immune response | 28 | |
| MRJ | DnaJ-like chaperone protein and corepressor of NF-ATs | 28 | |
| Runx2 and -3 | Runt domain transcription factors important for organogenesis | 72, 133 | |
| TEL (ETV6) | Ets-related transcription factor and leukemic fusion partner of Runx1 | 115 | |
| BCL6 | POZ finger transcription factor important for cell survival and differentiation | 87 | |
| BCoR | BCL6 corepressor important for embryogenesis | 69 | |
| PLZF | POZ finger transcription factor involved in leukemogenesis | 21, 87 | |
| HIF-1α | HIF controlling gene expression during oxygen tension | 77 | |
| CREB2 | Transcription factor regulating gene expression during synaptic growth | 55 | |
| GATA-1 | Transcription factor crucial for erythroid differentiation | 143 | |
| TR2 | Nuclear orphan receptor | 42 | |
| N-CoR | Nuclear receptor corepressor | 66, 74 | |
| SMRT | Nuclear receptor corepressor, highly similar to N-CoR | 66, 74 | |
| ARR19 | Androgen receptor corepressor | 71 | |
| Rea | Repressor of estrogen receptor activity | 85 | |
| RIP140 | Transcriptional corepressor for nuclear receptors | 17 | |
| ANCO-1 | Ankyrin repeat-containing cofactor for p160 nuclear receptor coactivators | 157 | |
| CtBP | E1A C-terminal binding protein, a transcriptional corepressor | 159 | |
| IκBα | Negative regulator of NF-κB | 1 | |
| HP1 | Heterochromatin protein 1, associated with the methyltransferase SUV39H1 | 160 | |
| TIP60 | Histone acetyltransferase | 86 | |
| ICP0 | Immediate-early gene product of the herpes simplex virus | 92 | |
| 53BP1 | p53 binding protein that regulates cell cycling in response to DNA damage | 73 | |
| ETR-A | G protein-coupled endothelin receptor | 86 | |
| HDAC6 | Tubulin | Deacetylating microtubules and increasing cell motility | 57, 68, 97, 108, 111, 163 |
| p150glued/dynactin | Adaptor protein for the molecular motors dyneins and kinesins | 68, 78 | |
| Ubiquitin | Signal for cellular processes, such as protein degradation and endocytosis | 64, 121 | |
| p97/VCP/Cdc48p | AAA ATPase in endoplasmic reticulum-associated proteosomal degradation | 121 | |
| PLAP | Phospholipase A2 activation protein controlling prostaglandin levels and phospholipase activity | 121 | |
| NF-κB (p50/65) | Transcription factor in inflammation and cell growth control | 162 | |
| Runx2 | Transcription factor essential for skeletal development | 145 | |
| LCoR | Transcriptional corepressor for agonist-bound nuclear receptors | 37 | |
| Sumoylated p300 | Transcriptional coregulator with lysine acetyltransferase activity | 45 | |
| PP1 | Phosphatase | 14 | |
| HDAC10 | LCoR | Transcriptional corepressor for ligand-bound nuclear receptors | 37 |
| PP1 | Phosphatase | 14 |