TABLE 2.

Class II human HDACs and potentially related diseases^a

HDAC	Chromosome	OMIMb no.	Human disease	Genetic analysis in model organisms
HDAC4	2q37.2	605314	Osteodystrophy	Segmentational defect in mutant flies; small size, chondrocyte hypertrophy, and exencephaly in null mice
HDAC5	17q21	605315	Cancer	Cardiac hypertrophy in mouse knockouts
HDAC6	Xp11.22	3000272	Neurodegenerative disorders	Required for formation of aggresomes and immune synapses in cultured cells
HDAC7	12q13.1	606542		Cardiovascular defects in null mice
HDAC9	7p12.1	606543	Peter’s anomaly	Cardiac hypertrophy in mouse knockouts
HDAC10	22q13.3	608544	Tumor metastasis	Not available

^aSee text for references.

^bOMIM, Online Mendelian Inheritance in Man database.