TABLE 2.

Assessments conducted in patients with cognitive complaints: Advisory board insights.

	Europe	US
Primary care	Short cognitive test (e.g., MMSE, MoCA, GPCOG, 6‐item screener, etc.) Blood tests (thyroid, calcium, HIV, syphilis, vitamin B12, folic acid) performed to investigate possible causes of dementia	Tests such as the Mini‐Cog are used to assess cognitive impairment, along with screening tests to eliminate alternate causes (e.g., depression screen, tests to eliminate thyroid, B12, and folate deficiency, and possibly MRI) Use of the Medicare Annual Wellness exam is encouraged for cognitive screening
Memory clinics	Neuropsychological assessment with blood tests conducted at the first visit to rule‐out treatable causes of cognitive impairment (e.g., thyroid, vitamin B12 deficiency, etc.) followed by a CT scan/MRI LP and/or PET are performed at subsequent visits, as indicated	Neuropsychological testing and CSF testing are usually done at this stage The frequency of CSF testing has spiked since the approval of aducanumab in June 2021

Note: Advisory boards convened in December 2021.

Abbreviations: CSF, cerebrospinal fluid; CT, computed tomography; GPCOG, General Practitioner assessment of Cognition; HIV, human immunodeficiency virus; LP, lumbar puncture; MMSE, mini‐mental state examination; MoCA, Montreal Cognitive Assessment; MRI, magnetic resonance imaging; PET, positron emission tomography; US, United States.