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. 2023 Dec 1;13(6):303–310. doi: 10.9740/mhc.2023.12.303

TABLE 5.

Multivariable Cox analyses: discontinuation with age, phenotype category, sex, and inhibitor/inducer use

Multivariable Cox Models – Fast Phenotype Group
	Overall		0 to 2 years		0 to 4 years
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Age (per decade)	0.87 (0.78, 0.96)	.008^a	0.87 (0.78, 0.96)	.009^a	0.87 (0.78, 0.97)	.011^a
Sex (male vs female)	1.09 (0.80, 1.49)	.58	1.10 (0.81, 1.50)	.54	1.10 (0.81, 1.50)	.56
Charlson comorbidity index	1.06 (1.00, 1.12)	.069	1.06 (1.00, 1.12)	.064	1.06 (1.00, 1.12)	.062
Inducer/inhibitor	0.63 (0.28, 1.43)	.27	0.55 (0.23, 1.33)	.18	0.54 (0.22, 1.33)	.18

Multivariable Cox Models – Middle Phenotype Group
	Overall		0 to 2 years		0 to 4 years
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Age (per decade)	0.92 (0.85, 0.98)	.014^a	0.91 (0.85, 0.98)	.009^a	0.91 (0.85, 0.98)	.011^a
Sex (male vs female)	0.92 (0.70, 1.21)	.56	0.93 (0.71, 1.22)	0.59	0.92 (0.70, 1.20)	.53
Charlson comorbidity index	1.03 (0.98, 1.08)	.19	1.04 (0.99, 1.09)	.17	1.03 (0.98, 1.09)	.19
Inducer/inhibitor	1.56 (1.09, 2.24)	.014^a	1.49 (1.04, 2.13)	.030^a	1.50 (1.05-2.15)	.026^a

Multivariable Cox Models –Slow Phenotype Group (n = 24, so only 2 variables)
	Overall		0 to 2 years		0 to 4 years
	HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Age (per decade)	0.93 (0.70, 1.23)	.59	0.92 (0.70, 1.21)	.55	0.93 (0.71, 1.23)	.61
Inhibitor/inducer	6.04 (2.47, 14.80)	<.001^a	4.85 (2.07, 11.39)	<.001^a	4.77 (2.05, 11.11)	<.001^a

^a

p-value < .05.