TABLE 1.

Putative Set2 homologs identified by PSI-BLAST searching with the SRI domain

Species	Gene namea	GI accession	Sequence position of putative SRI domain	% Identity/similarity to SRI domainb
S. cerevisiae	Set2	6322293	619-718	NA
Candida albicans	Ca019.9324	46435920	723-820	35/55
Homo sapiens	HYPB	30410779	1956-2056	23/37
Mus musculus	XP_135176	38090181	2393-2493	23/37
D. melanogaster	CG1716	24641786	2262-2356	21/39
Neurospora crassa	XP_322355	32403484	569-653	19/37
S. pombe	SPAC29B12	2408044	703-778	17/42

^aAll proteins identified contain a domain architecture similar to yeast Set2, including the AWS, SET, postSET and, in some cases, WW domains. It is notable that the putative SRI domains, as with Set2, are found in the C termini of these proteins.

^bIdentity refers to the percentage of identical amino acids present between the yeast Set2 SRI domain and the putative SRI domain of the indicated homolog, while similarity indicates amino acid replacements that exhibit similar charge or hydrophobicity.