Table 1.
Micromorphological quantitative assay of liver sections.
| Experimental Groups N = 6 | Hydropic Degenerationa (Mean %)b | Fatty Degenerationa (Mean %)b | Vascular Congestiona (Mean %)b | Inflammatory Cellsa (Mean %)b | Lesion Scoring (0–100 %) | Lesion Grading |
|---|---|---|---|---|---|---|
| (G1) NCGc | 5.37 %A# | 3.21 %A | 6.42 %A | 2.81 %A# | 0–10 % | No lesion |
| (G2) PCG (DOX) | 92.78 %E | 84.39 %E | 79.62 %E | 76.48 %E | 75–100 % | Critical |
| (G3) BZF + DOX | 75.61 %D | 69.56 %D | 70.85 %D | 74.55 %D | 50–75 % | Severe |
| (G4) GKB + DOX | 71.64 %D | 70.94 %D | 74.61 %D | 62.56 %D | 50–75 % | Severe |
| (G5) BZF + GKB + DOX | 50.69 %C | 49.72 %C | 53.82 %C | 48.51 %C | 25–50 % | Moderate |
Notes.
#Statistical comparison among groups: Mean values with different capital letters have significant differences at (P < 0.05).
Hepatocytes hydropic degeneration, fatty degeneration and inflammatory cells were estimated in (%) of cell numbers. Area of vascular congestion estimated in mean percentage of (μm).
Each value represents the mean percentage (n = 6).
G1: Negative control group (NCG), Distilled water; G2: Positive control group (PCG), Doxorubicin (DOX) 3.6 mg/kg; G3: Bezafibrate (BZF) group 100 mg/kg with DOX; G4: Ginkgo biloba (GKB) group 60 mg/kg with DOX; G5: Bezafibrate 100 mg/kg and Ginkgo biloba 60 mg/kg with DOX.