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. 2023 Oct 26;299(12):105400. doi: 10.1016/j.jbc.2023.105400

Figure 1.

Figure 1

Conserved structuresof selected members of the galectin family and structural classification. Based on their structural features, galectins are classified into three groups: “proto-type” galectins (e.g. GAL-1) contain one carbohydrate recognition domain (CRD) and can dimerize; “tandem repeat-type” galectins (e.g. GAL-4, GAL-8 and GAL-9) contain two distinct CRD in tandem, connected by a linker peptide; and “chimera-type” GAL-3 which consists of unusual proline- and glycine-rich short stretches fused onto the CRD. GAL-1 structure is shown in blue (PDB: 4Y1U); GAL-3 structure in green (PDB: 4R9A); GAL-4 N-CRD in turquoise (PDB: 5DUV) and GAL-4 C-CRD in steel blue (PDB: 4YM3); protease-resistant mutant GAL-8 form possessing both N-CRD (shown in orange), and C-CRD (shown in red), with a linker of two amino acids (His-Met) (shown in green) (PDB: 3VKM); protease-resistant mutant GAL-9 form possessing both N-CRD (shown in lilac) and C-CRD (shown in violet) with a linker of 19 amino acids (shown in green) and a metal ion found at the CRDs interface (PDB: 3WV6). All structures are represented in complex with lactose in yellow and GAL-8 N-CRD with SiaLac in cyan.