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Schematic representation of GAL-9-glycan interactions on selected cell surface receptors. GAL-9 binds to N- and O-glycans. It preferentially recognizes internal LacNAc residues. The N-terminal CRD of GAL-9 (GAL-9N) has a high affinity for gangliosides (e.g. GA1, GM1, GD1a) and other glycolipids (ended in e.g. Förssman pentasaccharide, A-hexasaccharide). LacNAc: Galβ1-4GlcNAc. Glycans are represented according to the symbol nomenclature proposed (244).
