Figure 1.
Experimental design
Three days before the first testing day, all participants come to the lab for a first habituation night under hd-EEG. On Day 1, participants undergo a first diffusion-weighted imaging (DWI1) session before being trained for 1 h on a motor sequence learning task (SRTT) in which each response key is associated with a specific auditory tone. Thirty minutes later, a second DWI (DWI2) session follows. During the subsequent night, subjects are either fully sleep deprived (1; SD) or get a regular night of sleep (2; RS) under hd-EEG. On the next morning, they all have a short behavioral retest. After 3 nights of regular sleep at home, participants come back for a 3rd DWI session (DWI3). Next, they are trained again on the SRTT for 40 min followed by a last DWI session (DWI4) and then task-related fMRI during which they were asked to perform the same SRTT task in the scanner for 20 min with a pseudo-random alternation between sequential and random blocks.